2型糖尿病患者成年后代糖尿病危险因素的流行

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Monica Gupta, Ruchika Saini, S. Jaswal, S. Lehl, Gautam Jesrani, Samiksha Gupta
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引用次数: 0

摘要

背景:T2DM患者的成年后代发生2型糖尿病(T2DM)及相关代谢异常的风险较高。各种遗传和环境影响起促进作用。这些决定因素可导致高血糖的早期发作、未被识别的终末器官改变和心血管疾病。目的:本研究的目的是确定T2DM患者的健康成年后代中未确诊的糖尿病和前驱糖尿病的存在,并研究这些个体的早期代谢异常。材料与方法:研究人群为100名18岁及以上的健康子女,父母均为2型糖尿病,来自医学门诊。评估了人体测量特征、常规调查和糖尿病定义参数、空腹血浆胰岛素和稳态模型评估-估计胰岛素抵抗(HOMA-IR)。结果:参与者的年龄和体重指数分别为32.30±9.33岁和25.08±4.58 kg/m2。约33.3%的雄性和76.4%的雌性存在腰围异常,26%的后代存在代谢综合征。28名参与者表现出血糖异常,其中10人被诊断为糖尿病前期,18人被诊断为糖尿病。新诊断T2DM患者c反应蛋白、总胆固醇、甘油三酯值、载脂蛋白A、B及其比值、HOMA-IR显著升高,高密度脂蛋白显著降低。结论:T2DM患者无症状子代中有相当一部分存在糖尿病早期和糖尿病前驱状态,目前尚不清楚。此外,新诊断的糖尿病和前驱糖尿病患者的代谢参数更加紊乱。因此,应定期对这些后代进行机会性筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of risk factors for diabetes in adult offspring of type 2 diabetes mellitus patients
Background: The risk of developing type 2 diabetes mellitus (T2DM) and associated metabolic abnormalities is higher in adult offspring of patients with T2DM. Various genetic and environmental influences play a facilitatory role. These determinants can lead to the early onset of hyperglycemia, unrecognized end-organ changes, and cardiovascular morbidity. Objective: The objective of this study was to identify the presence of undiagnosed diabetes and prediabetes in the otherwise healthy adult offspring of patients with T2DM and to study early metabolic abnormalities among these individuals. Materials and Methods: The study population consisted of 100 healthy offspring aged 18 years and above, of parents with T2DM, enrolled from the medicine outpatient area. Anthropometric characteristics, routine investigations and diabetes defining parameters, fasting plasma insulin, and homeostatic model assessment-estimated insulin resistance (HOMA-IR) were assessed. Results: The age and body mass index of participants were 32.30 ± 9.33 years and 25.08 ± 4.58 kg/m2, respectively. About 33.3% of males and 76.4% of females had abnormal waist circumference and metabolic syndrome was found in 26% of the offspring. Twenty-eight participants displayed dysglycemia, of which 10 were diagnosed with prediabetes and 18 with diabetes. C-reactive protein, total cholesterol, triglyceride values, apolipoprotein A, B, and their ratio, and HOMA-IR were significantly raised, and high-density lipoprotein was found significantly low in patients with this newly diagnosed T2DM. Conclusion: A significant number of asymptomatic offspring of patients with T2DM have incipient diabetes and prediabetes status, which is unidentified. Further, metabolic parameters are more deranged in those with newly diagnosed diabetes and prediabetes. Therefore, opportunistic screening for these offspring should be done routinely.
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