{"title":"巨噬细胞如何以及为什么与帕金森病有关:PD治疗策略的简要回顾","authors":"A. Chakraborty","doi":"10.31579/2692-9406/127","DOIUrl":null,"url":null,"abstract":"Chronic neuro-inflammation cause the neural cell death including dopaminergic cells and ultimate results Parkinson’s disease (PD). In an MPTP-induced PD animal model an increased peripheral pro-inflammatory M1 macrophages (M1- MFs) were found. Polarization of this M1-type of MFs to anti-inflammatory M2-type revealed a potential therapeutic benefit for PD patients. Here we highlight the concept of MFs re-education as a method of PD therapies, and how we can deploy our knowledge to find out therapeutic regimen for PD treatment.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How and Why Macrophages are Connected with the Parkinson’s Disease: A Short Review to Develop a Therapeutic Strategy for PD\",\"authors\":\"A. Chakraborty\",\"doi\":\"10.31579/2692-9406/127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chronic neuro-inflammation cause the neural cell death including dopaminergic cells and ultimate results Parkinson’s disease (PD). In an MPTP-induced PD animal model an increased peripheral pro-inflammatory M1 macrophages (M1- MFs) were found. Polarization of this M1-type of MFs to anti-inflammatory M2-type revealed a potential therapeutic benefit for PD patients. Here we highlight the concept of MFs re-education as a method of PD therapies, and how we can deploy our knowledge to find out therapeutic regimen for PD treatment.\",\"PeriodicalId\":72392,\"journal\":{\"name\":\"Biomedical research and clinical reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical research and clinical reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31579/2692-9406/127\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical research and clinical reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31579/2692-9406/127","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
How and Why Macrophages are Connected with the Parkinson’s Disease: A Short Review to Develop a Therapeutic Strategy for PD
Chronic neuro-inflammation cause the neural cell death including dopaminergic cells and ultimate results Parkinson’s disease (PD). In an MPTP-induced PD animal model an increased peripheral pro-inflammatory M1 macrophages (M1- MFs) were found. Polarization of this M1-type of MFs to anti-inflammatory M2-type revealed a potential therapeutic benefit for PD patients. Here we highlight the concept of MFs re-education as a method of PD therapies, and how we can deploy our knowledge to find out therapeutic regimen for PD treatment.
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