通过氧化石墨烯和聚乙烯醇修饰的磁性镁铁纳米颗粒控释抗癌药物:紫杉醇和多西紫杉醇

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
A. Gholami, B. Habibi, A. Matin, N. Samadi
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引用次数: 1

摘要

目的:紫杉醇(Paclitaxel, PTX)和多西紫杉醇(docetaxel, DTX)属于紫杉醇类药物,已被用于治疗卵巢癌、乳腺癌、肺癌、头颈癌、胃癌、胰腺癌、膀胱癌、前列腺癌和宫颈癌。控制药物释放系统通过改变药物的释放谱、生物分布、稳定性和溶解度、生物利用度以及减少抗癌药物的副作用来提高药物治疗的有效性。因此,本研究的目的是合成改性的纳米复合材料,以控制这些药物的释放。材料与方法:采用共沉淀法合成磁性氧化铁镁纳米颗粒,并与氧化石墨烯复合,再经聚乙烯醇改性。采用扫描电子显微镜(SEM)、x射线粉末衍射(XRD)、傅里叶变换红外光谱和振动样品磁强计对制备的纳米复合材料进行了理化表征。结果:研究了磁性纳米材料在抗癌药物控释中的吸附能力、单分散性、稳定性和亲水性等特性。采用紫外可见光谱法(UV-Vis)考察了不同pH条件下药物的载药量、载药率和释放率。PTX和DTX在改性磁性纳米复合材料中的DLE和DLC分别为85.2±2.7%和7.74±0.24%,89.4±1.2%和8.12±0.11%。在ph值为5.8、7.4时,纳米复合材料的PTX和DTX在100 h内的累积释放量分别为58%、40%和54%、37%。结论:改性纳米复合材料在药物递送系统中的潜力主要来自于磁芯的固有特性、载药能力以及不同表面涂层制备的改性纳米复合材料的生物医学性能。DTX(或PTX)的缓释特性有利于改性纳米复合材料在抗癌药物传递中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Controlled release of anticancer drugs via the magnetic magnesium iron nanoparticles modified by graphene oxide and polyvinyl alcohol: Paclitaxel and docetaxel
Objective(s): Paclitaxel (PTX) and docetaxel (DTX) belong to the family of taxanes drugs which have been employed for treatment of ovarian, breast, lung, head, neck, gastric, pancreatic, bladder, prostate and cervical cancer. Controlled drug release systems improve the effectiveness of drug therapy by modifying the release profile, biodistribution, stability and solubility, bioavailability of drugs and minimize the side effects of anticancer drugs. So, the purpose of the present study was to synthesize the modified nanocomposite for the controlled releases of these drugs.Materials and Methods: Magnetic magnesium iron oxide nanoparticles were synthesized via the co-precipitation chemical method and then composited with graphene oxide and modified by polyvinyl alcohol. The physicochemical characterization of the prepared nanocomposites was investigated by scanning electron microscope (SEM),  X-ray powder diffraction (XRD) , Fourier-transform infrared spectroscopy and vibrating-sample magnetometer.Results: Specific characteristics such as adsorption capacity, monodispersity, stability and hydrophilicity of magnetic nanomaterials were studied in the controlled release of anticancer drugs. Drug loading content and drug loading efficiency and release rate of drugs were investigated in vitro at different pH with ultraviolet-visible spectroscopy (UV-Vis). DLE and DLC of PTX and DTX in the modified magnetic nanocomposites were calculated  as 85.2 ± 2.7% and 7.74 ± 0.24% , 89.4 ± 1.2% and 8.12 ± 0.11% of, respectively. The cumulative release amount of PTX and DTX from magnetic modified nanocomposites at pHs 5.8, 7.4 over 100 h were 58 % and 40 % and 54 % and 37 %, respectively.Conclusion: The potential of modified nanocomposite in drug delivery systems from the intrinsic properties of the magnetic core combined with their drug loading capability and the biomedical properties of modified nanocomposite generated by different surface coatings. The generally sustained and controlled release profile of DTX (or PTX) facilitates the application of modified nanocomposite for the delivery of anticancer drugs.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
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审稿时长
12 weeks
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