抗糖尿病复方片的研制及评价

IF 0.4 Q4 PHARMACOLOGY & PHARMACY
Sushilkumar A. Shinde
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引用次数: 0

摘要

目的:本研究的目的是制备和测试由所选植物的几种提取物制成的抗糖尿病多糖片。植物通常是很好的药物来源。事实上,许多目前可获得的药物都是由植物直接或间接生产的。据报道,含有独特干植物提取物和几种赋形剂(如淀粉、微晶纤维素和滑石)的固体药物剂型的抗糖尿病活性具有统计学意义。材料和方法:本文还讨论了制备片剂的评价(重量变化、脆性、硬度和崩解时间)。结果和讨论:根据预成型实验的结果,所有值都在可接受的范围内。该配方具有相当的硬度(3.250.57),有助于其快速崩解。该制剂的脆性(0.290.03)表明该片剂是机械稳定的。由于片剂的平均重量为340mg,因此允许7%的重量变化。结论:结果表明,全成型片剂的重量变异试验合格。混合物花了一分钟多的时间才最终分解,可以得出结论,形成的片剂需要额外的研究来正确理解潜在的作用机制,以及长期的毒性测试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation and Evaluation of Antidiabetic Polyherbal Tablets
Aim: The goal of this study is to create and test antidiabetic polyherbal tablets made from several extracts of the chosen plant. Plants are usually a good source of medication. In reality, many currently accessible medications were produced from plants, either directly or indirectly. The anti-diabetic activity of a solid pharmaceutical dosage formulation containing a unique dry plant extract and several excipients such as starch, microcrystalline cellulose, and talc was reported to be statistically significant. Materials and Methods: The evaluation of prepared tablets is also discussed in this letter (weight variation, friability, hardness, and disintegration time). Results and Discussion: All of the values were within acceptable limits, according to the results of the preformulation experiments. The formulation has a fair amount of hardness (3.250.57), which aids in its rapid disintegration. The formulation’s friability (0.290.03) revealed that the tablets were mechanically stable. Because the average weight of the tablets was 340 mg, a weight variation of 7% is permissible. Conclusion: As a result, the weight variation test was passed on the full formed tablet. The mixtures took more than a minute to disintegrate finally, it may be concluded that the formed tablet requires additional research to properly understand the underlying mechanism of action, as well as long-term toxicity tests.
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来源期刊
Asian Journal of  Pharmaceutics
Asian Journal of Pharmaceutics PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
47
期刊介绍: Character of the publications: -Pharmaceutics and Pharmaceutical Technology -Formulation Design and Development -Drug Discovery and Development Interface -Manufacturing Science and Engineering -Pharmacokinetics, Pharmacodynamics, and Drug Metabolism -Clinical Pharmacology, General Medicine and Translational Research -Physical Pharmacy and Biopharmaceutics -Novel Drug delivery system -Biotechnology & Microbiological evaluations -Regulatory Sciences
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