Study of Severity of Syndrome-X on Lung Function Impairment in Indian Population

Background and Aim: Syndrome-X and impaired lung functions both have been associated with an increased jeopardy of coronary heart disease (CHD) in the middle aged Indian population. The aim of present study was to investigate the Severity of Syndrome-X on Lung Function Impairment in Indian Population. Methods: This cross sectional study was done among 200 syndrome-X patients at C. U. Shah Medical College, Gujarat, India for the period of three years from July 2012 to June 2015. They were divided into three groups on basis of presence of numbers of components of Syndrome-X. Syndrome-X was defined, National cholesterol Education Program’s-Adult Treatment Panel III Criteria. Anthropometric measurements, blood pressure and lung functions were measured. Fasting blood samples were analyzed to measured glucose, triglyceride and high-density lipoprotein (HDL-c) cholesterol. Statistical analysis was done by SPSS windows version 20.0 software. Results: The prevalence of components in syndrome-X patients was 48.5% with 3, 33.5% with 4 and 18% with 5 components of syndrome-X. The lung functions variables (FVC; P<0.05, FEV1; P<0.001, FEV3; P<0.05, FEFR; P<0.001 and FEF25-75%; P<0.0001) were significantly decreases in patients having 4 or 5 components of syndrome-X as compared to patients having 3 components. Conclusion: It is concluded from present study that the frequency of components of syndrome-X was significantly associated with lung functions impairment. Therefore, this study suggests that lung function test may be useful as an additional evaluation for the syndrome–X in a clinical practice.