具有抗癌活性的氟姜黄素衍生物动力学研究

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Joanna Kuźmińska, A. Sobczak, Izabela Muszalska-Kolos, A. Jelińska, Weronika Jankowska, T. Gośliński
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引用次数: 0

摘要

两种新型的含二氟硼基的氟姜黄素加合物在体外对两种膀胱癌细胞株5637和scer有活性。在模拟消化道和膀胱环境的生理相关条件下评估其稳定性。因此,实验分别在pH为1.2的盐酸和pH为4.5 - 6.8的缓冲溶液中进行,温度为37℃。一种经过验证的高效液相色谱方法,允许监测底物和产物浓度随时间的变化。值得注意的是,主要的分解产物是不含二氟硼基的氟姜黄素衍生物。氟姜黄素加合物分解为主要产物的过程为准一级动力学反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kinetic studies of fluorocurcumin derivatives with anticancer activity
Two novel fluorocurcumin adducts with a difluoroboryl group exhibited activity in vitro against two bladder cancer cell lines, namely 5637 and SCaBER. The stability was evaluated under physiologically relevant conditions to mimic both the digestive tract and the bladder environment. Therefore, experiments were performed in hydrochloric acid at pH 1.2, and in buffer solutions with pH from 4.5 to 6.8 at 37°C. A validated HPLC method, allowing the monitoring of changes in substrates and products concentrations over time, was applied. Notably, the main decomposition product was the fluorocurcumin derivative without the difluoroboryl group. The decomposition of the fluorocurcumin adducts to the major products undergoes the pseudo-first-order kinetics reaction.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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