TargetGeneReg 2.0:p53、p63和细胞周期依赖性基因调控的综合网络图谱

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
NAR cancer Pub Date : 2021-12-07 DOI:10.1093/narcan/zcac009
Martin Fischer, Konstantin Riege, R. Schwarz, J. Decaprio, Steve Hoffmann
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引用次数: 13

摘要

近年来,我们在www.TargetGeneReg.org上的web-atlas使许多研究人员能够发现新的生物学见解,并确定影响p53和细胞周期的新调节机制——在癌症等疾病中经常失调的信号通路。在这里,我们提供了数据库的实质性升级,包括扩展到包括非编码基因和转录因子ΔNp63和RFX7。TargetGeneReg 2.0结合了基因表达谱和转录因子DNA结合数据,以确定每个基因对p53、ΔNp63和细胞周期信号的反应。它可以用来剖析常见的、细胞类型和治疗特异性的影响,确定最有前景的候选者,并验证研究结果。我们用现实的例子展示了资源的强大功能和更直观的布局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation
In recent years, our web-atlas at www.TargetGeneReg.org has enabled many researchers to uncover new biological insights and to identify novel regulatory mechanisms that affect p53 and the cell cycle – signaling pathways that are frequently dysregulated in diseases like cancer. Here, we provide a substantial upgrade of the database that comprises an extension to include non-coding genes and the transcription factors ΔNp63 and RFX7. TargetGeneReg 2.0 combines gene expression profiling and transcription factor DNA binding data to determine, for each gene, the response to p53, ΔNp63, and cell cycle signaling. It can be used to dissect common, cell type, and treatment-specific effects, identify the most promising candidates, and validate findings. We demonstrate the increased power and more intuitive layout of the resource using realistic examples.
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CiteScore
6.90
自引率
0.00%
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审稿时长
13 weeks
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