l -半胱氨酸生物合成的最新进展、挑战和代谢工程策略

IF 3.3 3区农林科学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Fermentation-Basel Pub Date : 2023-08-31 DOI:10.3390/fermentation9090802

Wen-Wu Li, Zhen Zhou, Dan Wang

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引用次数: 0

摘要

l -半胱氨酸是一种被广泛使用的独特的含硫氨基酸，在食品、制药和农业工业中有着广泛的应用。综述了化学水解法、酶生物转化法和发酵法合成l -半胱氨酸的优缺点。同时，详细介绍了l -半胱氨酸的生物合成、代谢工程策略以及l -半胱氨酸发酵菌的最新研究进展。最后，对今后提高生物合成l -半胱氨酸产量的发展方向提出了见解。本文综述为今后开发更高效的l -半胱氨酸生物合成途径提供了思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advances, Challenges, and Metabolic Engineering Strategies in L-Cysteine Biosynthesis

L-Cysteine is a widely used unique sulfur-containing amino acid with wide application in the food, pharmaceutical, and agricultural industries. This paper concludes the advantages and disadvantages of chemical hydrolysis, enzymatic biotransformation, and fermentation for the synthesis of L-cysteine. Meanwhile, a detailed introduction is given to the biosynthesis of L-cysteine, metabolic engineering strategies, and the latest progress in reported L-cysteine fermentation bacteria. Finally, insights are provided on the development direction of increasing the production of biosynthetic L-cysteine in the future. This review provides ideas for the future development of more efficient L-cysteine biosynthetic pathways.

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来源期刊

Fermentation-Basel BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

3.80

自引率

18.90%

发文量

594

审稿时长

7 weeks

期刊介绍： Fermentation-Basel is an international open access journal published by MDPI, focusing on fermentation-related research, including new and emerging products, processes and technologies, such as biopharmaceuticals and biotech drugs. The journal enjoys a good reputation in the academic community and provides a high-impact forum for researchers in the field of bioengineering and applied microbiology.