Formulation and optimization of polyherbal Nanogel for dermatological applications

The aim of the present investigation was to develop a polyherbal nano gel (PHNG) formulation capable of acting as a potential vehicle to deliver polyherbal phytoconstituents topically. Individual herbs, according to Ayurveda, are insufficient to deliver the intended medicinal effect. It will have a better therapeutic impact with less toxicity when it is optimized as multiple herb combinations in a certain ratio. The objective of this study was to create a polyherbal gel for the delivery of medication from methanolic extracts of Plumbago zeylanica Linn, Datura stramonium Linn, and Argemone mexicana Linn. this work include methanolic extracts of Plumbago zeylanica stem, Datura stramonium leaves, Argimone Mexicana areal part. The polyherbal-based nanogel was prepared by low energy self-emulsification technique, and was evaluated for pH, viscosity and spreadability, stability, and drug release. The drug release profile of stable nanogel formulations was studied at various time intervals. Furthermore, the prepared nanogel was characterized by zeta-potential, zeta-sizer, and transmission electron microscopy (TEM). Optimized PHNG had particle size and zeta potential of 11.25nm and -25.73 mV respectively. TEM analysis of optimized formulation revealed the spherical shape of particles. Furthermore, the optimized formulation was found to possess higher stability with a maximum extended cumulative release of up to 240 minutes We have formulated a polyherbal nanogel that can be validated by physiochemical and surface characterization.