微波加速可持续合成WEPPA催化的2-氨基- 4h -铬:绿色策略

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Prashant B. Hiremath and Kantharaju Kamanna
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引用次数: 19

摘要

由于其毒性最小,易于生物降解,并且能够作为更环保的催化介质,农业废物作为来源提供了替代许多有毒和环境有害催化剂的极好选择。报道的一些基于农业废弃物的催化剂有BFE、WERSA、WEB和WEPBA。2-氨基- 4h -铬衍生物具有抗菌、抗炎、抗菌、抗病毒、抗癌、抗利尿、抗凝血和抗过敏等药理作用,是一种极具生物活性的杂环化合物。本文介绍了一种微波加速、高效、环保、经济的方法,通过取代芳醛、丙二腈和间苯二酚/萘酚催化石榴皮灰水提物(WEPPA)在微波辐射下缩合合成2-氨基- 4h -铬。反应在3-6分钟内完成,产品分离率良好。通过简单的过滤和再结晶分离得到的最终产物在光谱上是纯的,不需要进一步的纯化。以石榴皮灰水提物为农业废弃物衍生催化剂,在微波辐射下经济合成了2-氨基- 4h -铬衍生物。在不添加外源碱和添加剂的情况下,利用微波辐射以芳醛、丙二腈和间苯二酚/萘酚为原料合成了2-氨基-4 -铬。WEPPA作为溶剂介质和催化剂,在2-氨基- 4h -铬的合成中具有双重作用。建立了一种高效、简单、基于农业废弃物的微波合成方法,利用WEPPA作为高效催化剂,由芳醛、丙二腈和间苯二酚/α-萘酚/β-萘酚缩合反应合成2-氨基- 4h -铬衍生物。该方法是一种更环保、经济、环保的合成铬支架的方法。该方法的优点是无溶剂、无外部金属、无化学碱、反应时间短、分离产物收率高。催化剂是从农业废弃物中提取的,它有丰富的自然资源,因此使目前的方法更环保。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Microwave Accelerated Sustainable Approach for the Synthesis of 2-amino-4H-chromenes Catalysed by WEPPA: A Green Strategy
The agricultural wastes as a source offer an excellent alternative to replace many toxic and environmentally hazardous catalysts, due to their least toxicity, ease of biodegradability, and ability to act as a greener catalytic medium. Some of the agro-waste based catalysts reported are BFE, WERSA, WEB, and WEPBA. 2-Amino-4H-chromene derivatives are promising biologically potent heterocyclic compounds, due to their medicinal applications such as antimicrobial, anti-inflammatory, antibacterial, antiviral, anticancer, antidiuretic, anticoagulant and antianaphylactic activities. The present work describes a microwave accelerated, efficient, eco-friendly and economical approach for the synthesis of 2-amino-4H-chromenes through condensation of substituted arylaldehyde, malononitrile and resorcinol/naphthol catalyzed water extract of pomegranate peel ash (WEPPA) under microwave irradiation. The reaction completed within 3-6 min with good to excellent yield of product isolation. The final product isolated by simple filtration and recrystallization gave a spectroscopically pure form of product and did not require further purification.The pomegranate peel ash water extract as an agro-waste derived catalyst was employed under microwave irradiation for the economical synthesis of 2-amino-4H-chromene derivatives.The reported agro-waste based catalyst was obtained in the absence of external base, additives and solvent-free synthesis of 2-amino-4H-chromene using aryl aldehyde, malononitrile and resorcinol/ naphthol under microwave irradiation. WEPPA acts as a solvent media and catalyst, as it plays a dual role in the synthesis of 2-amino-4H-chromenes.We established an efficient, simple, agro-waste based catalytic approach for the synthesis of 2-amino-4H-chromene derivatives from the condensation of arylaldehyde, malononitrile and resorcinol/α-naphthol/β-naphthol employing WEPPA as an efficient catalyst under microwave synthesis. The method has found to be a greener, economic and eco-friendly approach for the synthesis of chromene scaffolds. The advantages of the present approach are solvent-free, no external metal, chemical base free, short reaction time and isolated product in good to excellent yields. The catalyst is agro-waste derived, which has abundant natural sources available, thus making the present approach a greener one.
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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