6-[18F]氟-左旋多巴PET/CT成像研究进展

中华核医学与分子影像杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2020.02.012

Jingnan Wang, Yaping Luo, L. Huo

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引用次数: 0

摘要

6-[18F]氟-L-多巴（18F-dopa）是左旋多巴类似物。18F-DOPA PET/CT成像被认为是诊断和评估帕金森病、脑肿瘤、嗜铬细胞瘤/副神经节瘤、神经母细胞瘤、胃肠道类癌、甲状腺髓样癌症和先天性高胰岛素血症的理想工具。本文综述了18F-DOPA的合成、定位机制、成像方法、临床适应证及研究进展。关键词：Levodopa；氟放射性同位素；正电子发射断层扫描；层析成像，X射线计算机；趋势

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Research progress of 6-[18F]fluoro-L-dopa PET/CT imaging

6-[18F]fluoro-L-dopa (18F-DOPA) is a levodopa analogue. 18F-DOPA PET/CT imaging is considered as an ideal tool in the diagnosis and evaluation of Parkinson′s disease, brain tumors, pheochromocytoma/paraganglioma, neuroblastoma, gastrointestinal carcinoid, medullary thyroid cancer and congenital hyperinsulinemia. This paper reviews the synthesis, mechanism of localization, imaging procedures, clinical indications and research advances of 18F-DOPA. Key words: Levodopa; Fluorine radioisotopes; Positron-emission tomography; Tomography, X-ray computed; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.