Volyn地区多发性硬化症的流行病学特征:一项前瞻性研究

O. Shulga, T. Mamchych
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摘要

背景:多发性硬化症(MS)是世界各地年轻人中枢神经系统疾病最常见的非创伤性原因,导致认知和身体残疾。约有20000名成年乌克兰人患有多发性硬化症。考虑到患病率和发病率,再加上环境、地区和城市化因素,前瞻性研究可以优化多发性痴呆症患者的医疗护理。以前从未在Volyn Polisia和Opillya地区进行过多发性炎的前瞻性研究。目的:前瞻性评估自然地理区域内沃林地区成年人群MS的患病率和发病率。材料和方法:采用流行病学和医学统计的发病率研究方法,研究Volyn地区MS患病率的特点。使用标准描述性统计和因子分析(主成分法)来估计一组指标的变化。因素分析包括自1999年以来Volyn地区多发性硬化症的发病率和患病率。此外,在2015年的MS发病率和2013年的p=0.001水平上,MS发病率存在统计学显著差异,显著性水平为p<0.1。因此,通过比较患病率和发病率,我们可以得出结论,Volyn Opillya地区的MS患病率明显高于Volyn Polisia地区。采用因子分析(主成分法)确定潜在因素。结果发现,三因素模型可以描述一组指标88%以上的变化:第一(主要)因素描述69%,第二-12,6%,第三-6,6%(合计88.2%)。结论:沃林州MS的患病率和发病率不均衡。Volyn Polisia地区的MS患病率低于Volyn Opillia地区。所开发的三因素模型可以描述88%以上的多发性硬化症人群患病率变化。我们认为,建议综合考虑多发性痴呆症的发病率和患病率,同时考虑环境、地区、城市和(不排除)工业指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiological characteristics of multiple sclerosis in Volyn region: a prospective study
Background: Multiple sclerosis (MS) is the most common non-traumatic cause of central nervous system disorders in young people worldwide, leading to cognitive and physical disability. About 20,000 of adult Ukrainians suffer from MS. Prospective studies, taking into account the prevalence and incidence, combined with environmental, territorial and urbanization factors can optimize medical care for patients with MS. A prospective study of MS within Volyn Polissia and Opillya zones has not been conducted before. Objective: To evaluate prospectively the prevalence and morbidity rates of MS among the adult population of Volyn region within the physical-geographical zones. Materials and methods: Epidemiological and medical-statistical methods of morbidity study were used to study features of MS prevalence in the Volyn region. The standard descriptive statistics and factor analysis (principal component method) were used to estimate the variation of a set of indicators. Factor analysis included incidence and prevalence rates of MS in Volyn region since 1999. Results: A statistically significant difference in MS prevalence at the significance level p <0.05 was found in the MS prevalence in 2014 and at the p = 0.005 level in the 2015–2017 section. Also, a statistically significant difference in the incidence of MS at a significance level of p <0.1 was detected in the incidence of MS in 2015 and at the level of p = 0.001 in 2013. Thus, comparing the prevalence and incidence rates, we can conclude that the prevalence of MS in the Volyn Opillya region is significantly higher than in the Volyn Polissia area. Factor analysis (principal component method) was conducted to identify latent factors. As a result, it was found that the 3-factor model allows to describe more than 88% of the variation of the set of indicators: the 1st (main) factor describes 69%, the 2nd - 12,6%, the 3rd - 6,6% (together 88,2%). Conclusions: The prevalence and incidence rates of MS in the Volyn Oblast were found to be uneven. The prevalence of MS in the Volyn Polissia area is lower than in the Volyn Opillia region. The developed 3-factor model allows to describe more than 88% of the variation of the population prevalence of MS. In our opinion, it is advisable to consider the incidence and prevalence rates of MS comprehensively, taking into account environmental, territorial, urban and, not excluded, industrial indicators.
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