结直肠癌患者手术前后血清同型半胱氨酸、VEGF、TGF-β1的动态变化

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2019-01-01 DOI:10.1515/pteridines-2019-0014

Yayi Ni, Lihua Xue, Guangbo Zhu, Yangrong Chen

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引用次数: 2

摘要

摘要背景:本研究旨在评价结直肠癌患者手术前后血清同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)和转化生长因子β1 (TGF-β1)的动态变化。材料与方法:本研究纳入118例手术治疗的结直肠癌患者(CRC组)和56例健康对照(对照组)。采用酶循环和酶联免疫吸附试验(ELISA)检测两组患者血清Hcy、VEGF TGF-β1水平。随访12个月，118例结直肠癌患者中有14例复发。术前、术后检测血清Hcy、VEGF、TGF-β1，每2个月重复一次。结果CRC组血清Hcy、VEGF、TGF-β1分别为16.20±4.79 μmol/L、492.36±97.32 pg/ml、29.23±7.47 pg/ml，对照组分别为8.98±3.02 μmol/L、315.21±56.28 pg/ml、7.69±2.31 pg/ml。复发与非复发CRC患者术后血清Hcy、VEGF、TGF-β1均显著降低(p<0.05)。有趣的是，血清Hcy、VEGF、TGF-β1随时间逐渐升高。结论结直肠癌患者血清Hcy、VEGF、TGF-β1水平升高，可能与术后疾病复发有关。

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Serum Homocysteine, VEGF and TGF-β1 dynamic change in colorectal cancer patients prior and post-operation

Abstract Background: The aim of the study was to evaluate the serum homocysteine (Hcy), vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) dynamic change in colorectal cancer patients pre- and post-operation. Material and methods: One hundred and eighteen CRC patients treated with surgery (CRC group) and 56 healthy controls (Control group) were included in this work. The serum Hcy, VEGF TGF-β1 were examined by enzymatic cycle and enzyme-linked immunosorbent assay (ELISA) of the two groups. We followed patients for 12 months and out of the 118 CRC patients, 14 patients had recurrent disease. Serum Hcy, VEGF and TGF-β1 were measured before and after surgery and repeated every 2 months. Results Serum Hcy, VEGF and TGF-β1 were 16.20 ± 4.79 μmol/L, 492.36 ± 97.32 pg/ml, 29.23 ± 7.47 pg/ml for the CRC group and 8.98 ± 3.02 μmol/L, 315.21 ± 56.28 pg/ml, 7.69 ± 2.31 pg/ml for the control groups. Serum Hcy, VEGF and TGF-β1 was significantly (p<0.05) lower after surgery in both recurrent and nonrecurrent CRC patients (p<0.05). Interestingly, serum Hcy, VEGF and TGF-β1 gradually increased with time. Conclusion Serum Hcy, VEGF and TGF-β1 levels are elevated in CRC patients and may correlated with the post-operative disease recurrence.

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.