桂兰地中海贫血患者肺动脉高压的患病率是多少?回顾性分析研究

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Seyyed Fakhr-Moosavi, A. Salari, Yasaman‐Sadat Borghei, T. Hasandokht, A. Haghdoost, S. Mousavi, Sajad Ramezani
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引用次数: 0

摘要

引言:肺动脉高压(PH)在地中海贫血患者中很常见,可导致心力衰竭甚至死亡。方法:这项横断面研究是对近年来在伊朗拉什特拉齐医院就诊的155名β-地中海贫血重度和中间型地中海贫血患者进行的。所有患者都接受了超声心动图检查,数据(包括年龄、性别、地中海贫血类型、脾切除术史、去铁胺使用情况、羟基脲使用情况、血红蛋白和铁蛋白水平)由研究人员编制的检查表收集。数据分析采用SPSS软件进行。结果:本研究中PH的患病率为13.7%。性别、地中海贫血类型、去铁胺使用量和铁蛋白水平与PH患病率之间存在相关性。然而,脾切除术史、羟基脲使用量和血红蛋白水平与PH发病率之间没有显著关系(分别为P=0.187、P=0.035和P=0.178)。结论:研究结果表明,所提出的变量会导致和加剧心脏并发症,并可能与疾病的副作用有关。利用这项研究和类似研究的结果,通过进行更多的研究并设计一项更具前景的更高样本量的介入研究,可以采取措施更早地识别易受心脏并发症恶化影响的患者。通过治疗他们,从长远来看,我们可能能够增加他们的生存机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What is the Prevalence of Pulmonary Hypertension in Thalassemic Patients in Guilan? A Retrospective Analytic Study
Introduction: Pulmonary hypertension (PH) is quite common among patients with thalassemia, and it can lead to cardiac failure and even death in those patients. Methods: This current cross-sectional study was conducted with 155 patients with β-thalassemia major and thalassemia intermedia referring to Razi Hospital Rasht, Iran in a recent year. All patients underwent echocardiography and the data (including age, sex, thalassemia type, splenectomy history, deferoxamine usage, hydroxyurea usage, hemoglobin, and ferritin level) were collected by a researcher-made checklist. Data analysis was performed using SPSS software. Results: The prevalence of PH was 13.7% in this study. There was a correlation between sex, thalassemia type, deferoxamine usage, and ferritin level with a prevalence of PH. However, there was not a significant relationship between splenectomy history, hydroxyurea usage, and hemoglobin level with PH prevalence (P = 0.187, P = 0.035, and P = 0.178, respectively). Conclusions: The findings of the study represented that the proposed variables can cause and exacerbate cardiac complications and may have a correlation with the disease's side effects. By conducting more studies and designing a more promising interventional study with a higher sample size, using the results of this study and similar studies, a step could be taken to identify patients susceptible to exacerbation of cardiac complications earlier. By treating them, we may be able to increase their chance of survival in the long run.
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来源期刊
Research in Cardiovascular Medicine
Research in Cardiovascular Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-
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审稿时长
17 weeks
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