Long Non-coding RNA Landscape in Colorectal Cancer

Increasing number of reports have shown the involvement of LncRNAs in the tumour progression in multiple cancers including colorectal and female reproductive cancers such as ovarian and breast. In particular, the profiling of lncRNAs in colorectal cancer (CRC), which is within the top three cancers in both female and male, have identified 556 upregulated and 1040 downregulated lncRNAs as compared to normal tissue. In this highlight, we looked at the mechanism in which some of these lncRNAs can act in CRC development and progression through promoting survival, proliferation and invasion and metastasis. Furthermore, we also look into the possibility of a cytoskeletal protein, gelsolin and its possible interaction with lncRNAs.