Cindy Cline, K. Fray, Bruce A. Furr, L. Pendarvis, C. Pritchard, Nicholas Strauss, K. Arnoldi
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In a retrospective cohort study of 114 adult patients with OMS, the authors report the clinical and immunological features of idiopathic OMS (I-OMS) and paraneoplastic OMS <P-OMS). Forty-five (39%) had P-O~S and 69 (61%) had I-OMS. The most frequently associated tumors in P-OMS were lung ( 42%) and breast (22%) carcinomas and ovarian teratoma (18%) in younger cases. Patients with I-OMS were younger than those with P-OMS (median age, 38 vs 54 years; p<0.001), presented more often with prodromal symptoms or active infection (33% vs 13%; p=0.02), less frequently had encephalopathy (10% vs 29%; p=O.Oll, and had better outcome (84% vs 39%; p<0.001) with fewer relapses (7% vs 24%; p=0.04). These results suggest that older age and encephalopathy significantly associate with P-OMS and are clinical clues suggesting an underlying tumor. Patients with I-OMS respond better to treatment and have fewer relapses. The clinical differences between P-OMS and I-OMS suggest different mechanisms of the disease per the trigger agent. They concluded that future studies looking to identify immunological mechanisms of OMS should focus on methods different from those used in autoimmune encephalitis and cell surface antigens. Francesco Graus, MD, PhD, Service of Neurology, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain e-mail: fgraus@clinic.cat ASLAM T, TAHIR H, PARRY N, MURRAY I, KWAK K, REYES R, SALLER M, CZANNER G, ASHWORTH J: Automated Measurement of Visual Acuity in Pediatric Ophthalmic Patients Using Principles of Game Design and Tablet Computers. Am J Ophthalmol 2016; 170:223-227. The purpose of this study was to determine the effectiveness of a touch screen game type visual acuity assessment by the Mobile Assessment of Vision by Interactive Computer for Children (MAVERIC-CJ. The study included 112 children between the ages of four and 16 years old. Children were not included if they were unable to use the device. Of the 112 children included, 95% were able to complete the test© 2017 Board of Regents of the University of Wisconsin System, American Orthoptic Journal, Volume 67, 2017, ISSN 0065-955X, E-ISSN 1553-4448","PeriodicalId":76599,"journal":{"name":"The American orthoptic journal","volume":"67 1","pages":"121 - 94"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/0065955X.2017.12023640","citationCount":"0","resultStr":"{\"title\":\"Abstracts of the Ophthalmic Literature\",\"authors\":\"Cindy Cline, K. Fray, Bruce A. Furr, L. Pendarvis, C. Pritchard, Nicholas Strauss, K. Arnoldi\",\"doi\":\"10.1080/0065955X.2017.12023640\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"s of the Ophthalmic Literature Compiled by: Cindy Cline, C.O. Katherine Fray, C.O. Bruce Furr, Ph.D., C.O. Lauren Pendarvis, C.O. Cindy Pritchard, C.O. Nicholas Strauss, C.O. Kyle Arnoldi, C.O. ARMANGUE T, SABATER L, TORRES-VEGA E, MARTiNEZ-HERNANDEZ E, ARINO H, PETITPEDROL M, PLANAGUMA J, BATALLER L, DALMAU J, GRAUS F: Clinical and immunological features of opsoclonus-myoclonus syndrome in the era of neuronal cell surface antibodies. JAMANeurol2016; 73:417-421. Opsoclonus-myoclonus syndrome (OMS) is a rare condition characterized by involuntary, arrhythmic, multidirectional saccades accompanied by myoclonic jerks in the limbs and trunk, cerebellar ataxia, tremor and encephalopathy. In a retrospective cohort study of 114 adult patients with OMS, the authors report the clinical and immunological features of idiopathic OMS (I-OMS) and paraneoplastic OMS <P-OMS). Forty-five (39%) had P-O~S and 69 (61%) had I-OMS. The most frequently associated tumors in P-OMS were lung ( 42%) and breast (22%) carcinomas and ovarian teratoma (18%) in younger cases. Patients with I-OMS were younger than those with P-OMS (median age, 38 vs 54 years; p<0.001), presented more often with prodromal symptoms or active infection (33% vs 13%; p=0.02), less frequently had encephalopathy (10% vs 29%; p=O.Oll, and had better outcome (84% vs 39%; p<0.001) with fewer relapses (7% vs 24%; p=0.04). These results suggest that older age and encephalopathy significantly associate with P-OMS and are clinical clues suggesting an underlying tumor. Patients with I-OMS respond better to treatment and have fewer relapses. The clinical differences between P-OMS and I-OMS suggest different mechanisms of the disease per the trigger agent. They concluded that future studies looking to identify immunological mechanisms of OMS should focus on methods different from those used in autoimmune encephalitis and cell surface antigens. Francesco Graus, MD, PhD, Service of Neurology, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain e-mail: fgraus@clinic.cat ASLAM T, TAHIR H, PARRY N, MURRAY I, KWAK K, REYES R, SALLER M, CZANNER G, ASHWORTH J: Automated Measurement of Visual Acuity in Pediatric Ophthalmic Patients Using Principles of Game Design and Tablet Computers. Am J Ophthalmol 2016; 170:223-227. The purpose of this study was to determine the effectiveness of a touch screen game type visual acuity assessment by the Mobile Assessment of Vision by Interactive Computer for Children (MAVERIC-CJ. The study included 112 children between the ages of four and 16 years old. Children were not included if they were unable to use the device. 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