毛细管电泳在中药表征中的进展和策略:近十年(2011-2021)综述

S. Shamsi, Jalpa U. Patel
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引用次数: 1

摘要

虽然中药被认为是药物发现的宝贵资源,并构成了药物开发的潜在基础,但由于药物不良反应和对其作用机制的了解不足,它们也存在巨大的安全风险。然而,由于中药的成分非常复杂,必须开发和推广有效的分析方法。对已发表的研究和科学论文的广泛检索表明,毛细管电泳(CE)的效率和灵敏度的提高引起了人们的广泛关注。本综述对过去十年(2011-2021年)公开文献中发表的用于中药分析的CE应用进行了深入评估。我们的调查结果表明,毛细管区带电泳(CZE)与紫外(UV)检测是一种毛细管电迁移技术,经常用于高效分离,鉴定和定量各种有效成分的高度复杂的基质。采用不同的提取方法、背景电解质改性剂、预富集技术和质谱(MS)检测器来提高CE的分离选择性和TCM的灵敏度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and strategies for capillary electrophoresis in the characterization of traditional Chinese medicine: A review of the past decade (2011–2021)
While traditional Chinese medicine (TCM) is considered a valuable resource for drug discovery and form a potential basis for drug development, they also carry substantial safety risks due to adverse drug reactions and a lack of understanding of their mechanisms of action. However, due to their highly complex composition, valid analytical methodologies for analyzing TCMs must be developed and promoted. An extensive search of published research and review of scientific papers implies that the increased efficiency and sensitivity of capillary electrophoresis (CE) has attracted much research attention. This review provides an in-depth assessment of CE applications for TCM analysis published in the open literature in the last decade (2011–2021). Our survey findings showed that capillary zone electrophoresis (CZE) with ultraviolet (UV) detection is a capillary electromigration technique frequently utilized for the efficient separation, identification, and quantitation of various active components in highly complex matrices. Different extraction methods, modifiers to the background electrolyte, preconcentration techniques, and mass spectrometry (MS) detectors are used to enhance CE separation selectivity and TCM sensitivity.
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