螺旋藻:对我们免疫系统的日常支持

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Subbu Vasudevan, S. Seetharam, Margaret Dohnalek, Elizabeth Cartwright
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引用次数: 0

摘要

近年来,蓝藻微藻的各种健康益处引起了科学界的关注,包括对其生物活性成分的微观检查。作为一种完整的食物和营养补充剂,它是一种植物蛋白来源,在从营养不良到代谢综合征的一系列人类健康问题上都表现出了积极的影响。螺旋藻的生物活性物质,如必需氨基酸、藻蓝蛋白、多糖、类胡萝卜素和叶绿素,以及必需维生素和微量矿物质,负责其对抗氧化应激和炎症的整体作用,以及抗病毒、抗菌和免疫调节作用。各种体外、体内和离体实验已经确立了螺旋藻的作用机制及其对免疫的影响,以此作为概念的证明。螺旋藻全食物消化后释放的酚类化合物和细胞外代谢产物被认为可以增强上皮衬里,对病原菌具有抗菌作用,由于其纤维含量,增加了其对肠道微生物群(如双歧杆菌和乳酸杆菌)的益生元作用。在本研究中,通过在模拟静态消化模型系统中测定消化各阶段的游离氨基酸和肽释放来评估螺旋藻的消化率。从长远来看,将肠道健康状况不佳与低水平炎症和代谢综合征联系起来的假设,以及通过营养补充剂(如螺旋藻)解决这些问题的潜力,也可能有利于减少共病,例如与当前流行的2019冠状病毒病大流行相关的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spirulina: A daily support to our immune system
In recent years, the various health benefits of Cyanobacteria microalgae – such as Arthrospira platensis, commonly called Spirulina, an edible blue-green algae – have attracted scientific attention including micro-level examinations of its bioactive components. As a whole food and nutritional supplement, it serves as a plant protein source, which has shown positive effects across a wide range of human health concerns, from malnutrition to metabolic syndrome. Spirulina bioactives, such as essential amino acids, phycocyanin, polysaccharides, carotenoids, and chlorophyll, and essential vitamins and trace minerals, are responsible for its holistic actions against oxidative stress and inflammation, and its antiviral, antibacterial, and immune-modulating effects. Various in vitro, in vivo, and ex vivo experiments have established Spirulina's mechanism of action and its effect on immunity as a proof of concept. The phenolic compounds and extracellular metabolites released from Spirulina whole food after digestion are postulated to strengthen the epithelial lining with antibacterial effects against pathogenic bacteria, adding to its prebiotic effect on the gut microbiota (like Bifidobacterium and Lactobacillus) due to its fiber content. In this study, the digestibility of Spirulina was assessed by the determination of free amino acids and peptide release during the each phase of digestion in a simulated static digestive model system. The hypothesis bridging poor gut health to low-level inflammation and metabolic syndrome, and the potential to address those issues with nutritional supplementation, such as with Spirulina, could also be beneficial in the long run to reduce comorbid illnesses, such as those associated with the currently prevailing coronavirus disease 2019 pandemic.
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