Incidencia de mutaciones genéticas en pacientes con cáncer de mama y ovario con patrón de origen hereditario

OBJECTIVE: To determine the genetic mutations in hereditary pattern breast cancer and demonstrate whether there is a significant association between the most common in the Mexican population and the risk of suffering it. MATERIALS AND METHODS: Cross-sectional and observational study conducted at the Hospital Angeles México in coordination with the National Institute of Genomic Medicine. Inclusion criteria: patients with breast cancer and one or more first-degree relatives affected by this disease and patients with ovarian cancer. Exclusion criteria: patients without a history of breast or ovarian cancer, or with a family member in the protocol. The RT2 Profiler plate rearrangement technique was used for Master-Mix Quantinova probe PCR kit. The SPSS version 22 program and Epi Info version 7 were used for the statistical analysis. RESULTS: 39 patients with an average age of 53.2 ± 12.1 years were studied. Pro- gesterone and estrogen receptors showed no difference between groups. There was a statistical difference, and CONCLUSION: The data obtained show that in the Mexican population the BRCA2 has a higher incidence in hereditary cancer, at an age of earlier onset and greater nuclear grade at the time of diagnosis.