间充质干细胞——主要的免疫调节剂

Mehak Vohra, S. Arora
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引用次数: 0

摘要

间充质干/基质细胞(MSCs)被称为多能细胞,因为它们能够分化为中胚层来源的各种细胞谱系。干细胞生物学的最新发展为治疗尚未治疗的疾病和病症提供了新的希望。这些细胞已被广泛用于动物和人类的临床试验。迄今为止,已有920多项与MSCs在各种条件下作为细胞治疗相关的人类临床试验。本文综述了间充质干细胞的特征,评价了其免疫特性、决定其可溶性因子的间充质细胞的活化、可能的途径、间充质红细胞与免疫细胞相互作用的机制,以及间充质基质干细胞在不同疾病中的各种应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesenchymal stem cells—the master immunomodulators
Mesenchymal stem/stromal cells (MSCs) are known as multipotent cells due to their ability to differentiate into various cell lineages of mesoderm origin. Recent developments in stem cell biology have provided a new ray of hope for the treatment of diseases and disorders that are yet to be treated. These cells have been widely used in animals and clinical trials in humans. To date, there are more than 920 clinical trials on humans related to MSCs as cell-based therapy in various conditions. The purpose of this review is to provide a summary of the characteristics of MSCs, evaluate their immunological properties, activation of MSCs that dictate their soluble factors, possible pathway, and mechanisms involved by MSCs and immune cell interaction, and various application of MSCs in different diseases.
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