Enigmol及其类似物治疗药物合成策略的综合研究

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2022-08-20 DOI:10.2174/1570193x19666220820115630

Parleen Kaur, Vasundhara Singh

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引用次数: 0

摘要

1-脱氧鞘脂是一类缺乏一级羟基(C1-OH)的鞘脂。因此，它不会被转化/降解为复杂的相应产物，如鞘氨醇-1-磷酸(SIP)，一种促有丝分裂物质。Enigmol是一种口服生物可利用的1-脱氧磷脂，具有对抗多种不同类型癌细胞的潜力，同时具有令人印象深刻的细胞毒性/抗增殖特性。由于其独特的结构性质，Enigmol及其类似物引起了合成有机化学家的极大关注。这篇综述提供了所有的合成方法被遵循的合成Enigmol和它的结构类似物的概述。

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Comprehensive Insight into Synthetic Strategies of Enigmol and Its Analogs as Therapeutic Agents

1-Deoxysphingolipids are a class of sphingolipids which lacks the primary hydroxyl group (C1-OH). Hence, it does not get converted/degraded to complex corresponding products like sphingosine-1-phosphate (SIP), a pro-mitotic. Enigmol, an orally bioavailable 1-deoxyphingolipid has shown potential against various different types of cancer cells along with impressive cytotoxic/antiproliferative properties. Due to its unique structural properties, Enigmol and its analogs have attracted considerable attention from synthetic organic chemists. This review provides an overview of all the synthetic approaches being followed for the synthesis of Enigmol and its structural analogs.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry