A case report of hebephrenic schizophrenia in intellectual disability with subependymal heterotopia

Subependymal heterotopia (SH), also commonly known as periventricular nodular heterotopia, is believed to result from a faulty neuronal migration which is associated with seizure disorders and intellectual disability. Intellectual developmental delay (IDD) is a condition of arrested or incomplete development of mind with the impairment of intelligence. Although SH and IDD co-occur often, cases of schizophrenia in SH with IDD are less commonly reported. A thorough search of scientific databases with keywords of IDD, SH, and schizophrenia on PubMed, Scopus, and Google Scholar combined yielded limited results, prompting us to report this case of SH without any history of seizures who developed hebephrenic Schizophrenia. This highlights the need to check for the presence of SH by MRI scan in individuals with IDD and psychosis.