V. Constantinides, G. Paraskevas, F. Boufidou, Maria Bourbouli, P. Paraskevas, L. Stefanis, E. Kapaki
{"title":"脑脊液淀粉样蛋白β和tau蛋白与非典型帕金森病的关系","authors":"V. Constantinides, G. Paraskevas, F. Boufidou, Maria Bourbouli, P. Paraskevas, L. Stefanis, E. Kapaki","doi":"10.20517/2347-8659.2019.22","DOIUrl":null,"url":null,"abstract":"Progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy and dementia with Lewy bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson’s disease. multiple system atrophy, dementia with Lewy bodies and Parkinson’s disease are synucleinopathies, whereas progressive supranuclear palsy and corticobasal degeneration are tauopathies. Multiple cerebrospinal fluid markers have been applied on cohorts of patients with Parkinsonism, with the aim to develop biomarkers for these disorders. Total tau (τΤ), phosphorylated tau at threonine 181 (τP-181) and amyloid-beta with 42 amino acids (Aβ42) are considered classical biomarkers for Alzheimer’s disease. The aim of the present study is to review the literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism, as well as present data on novel approaches regarding analysis of these proteins.","PeriodicalId":19129,"journal":{"name":"Neuroimmunology and Neuroinflammation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Cerebrospinal fluid amyloid beta and tau proteins in atypical Parkinsonism: a review\",\"authors\":\"V. Constantinides, G. Paraskevas, F. Boufidou, Maria Bourbouli, P. Paraskevas, L. Stefanis, E. Kapaki\",\"doi\":\"10.20517/2347-8659.2019.22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy and dementia with Lewy bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson’s disease. multiple system atrophy, dementia with Lewy bodies and Parkinson’s disease are synucleinopathies, whereas progressive supranuclear palsy and corticobasal degeneration are tauopathies. Multiple cerebrospinal fluid markers have been applied on cohorts of patients with Parkinsonism, with the aim to develop biomarkers for these disorders. Total tau (τΤ), phosphorylated tau at threonine 181 (τP-181) and amyloid-beta with 42 amino acids (Aβ42) are considered classical biomarkers for Alzheimer’s disease. The aim of the present study is to review the literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism, as well as present data on novel approaches regarding analysis of these proteins.\",\"PeriodicalId\":19129,\"journal\":{\"name\":\"Neuroimmunology and Neuroinflammation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimmunology and Neuroinflammation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.20517/2347-8659.2019.22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunology and Neuroinflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20517/2347-8659.2019.22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cerebrospinal fluid amyloid beta and tau proteins in atypical Parkinsonism: a review
Progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy and dementia with Lewy bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson’s disease. multiple system atrophy, dementia with Lewy bodies and Parkinson’s disease are synucleinopathies, whereas progressive supranuclear palsy and corticobasal degeneration are tauopathies. Multiple cerebrospinal fluid markers have been applied on cohorts of patients with Parkinsonism, with the aim to develop biomarkers for these disorders. Total tau (τΤ), phosphorylated tau at threonine 181 (τP-181) and amyloid-beta with 42 amino acids (Aβ42) are considered classical biomarkers for Alzheimer’s disease. The aim of the present study is to review the literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism, as well as present data on novel approaches regarding analysis of these proteins.
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