微乳作为尼莫地平的潜在递送系统

European Pharmaceutical Journal Pub Date : 2023-08-24 DOI:10.2478/afpuc-2023-0004

M. Čuchorová, M. Špaglová, M. Martina Papadakos

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引用次数: 0

摘要

摘要制药技术中一个重要的研究领域是难溶性药物及其制剂，以确保最佳生物利用度。解决溶解度问题的选择之一是开发纳米分散体系。本工作的重点是制备适用于难溶性药物的微乳体系，如尼莫地平。微乳液的组成和结构使不同药物能够增溶，成为一种通用的药物载体。与在水中的溶解度相比，微乳使模型药物的溶解度增加了20倍。使用粘性聚合物——羟乙基纤维素和黄原胶——显著改善了体外释放。从含有羟乙基纤维素（1%w/w）的微乳液凝胶体系中释放出最高量的尼莫地平，这取决于溶解分子的扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microemulsions as the Potential Delivery System for Nimodipine

Abstract An important area of interest in pharmaceutical technology is the issue of poorly soluble drugs and their formulation into drug dosage forms that ensure optimal bioavailability. One of the options to solve solubility is the development of nanodispersion systems. This work is focused on the preparation of microemulsion systems suitable for poorly soluble drugs, for example, nimodipine. The composition and structure of microemulsion enable solubilization of different drugs and make it a universal drug carrier. Microemulsions increased the solubility of the model drug 20-fold compared to solubility in water. The use of mucoadhesive polymers – hydroxyethyl cellulose and xanthan gum – improved the in vitro release significantly. The highest amount of nimodipine was released from the microemulsion gel system with hydroxyethyl cellulose (1% w/w) and this depended on the diffusion of dissolved molecules.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.