{"title":"人β防御素-2治疗方式在糖尿病创面治疗中的前瞻性意义。","authors":"Vidyasrilekha. Yele, Bharat Kr Sanapalli","doi":"10.25270/wmp.2023.2.22084","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nDiabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.\n\n\nPURPOSE\nThe current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.\n\n\nMETHODS\nThis review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.\n\n\nRESULTS\nHBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.\n\n\nCONCLUSION\nIt has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.\",\"authors\":\"Vidyasrilekha. Yele, Bharat Kr Sanapalli\",\"doi\":\"10.25270/wmp.2023.2.22084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nDiabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.\\n\\n\\nPURPOSE\\nThe current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.\\n\\n\\nMETHODS\\nThis review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.\\n\\n\\nRESULTS\\nHBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.\\n\\n\\nCONCLUSION\\nIt has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.\",\"PeriodicalId\":23741,\"journal\":{\"name\":\"Wound management & prevention\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wound management & prevention\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.25270/wmp.2023.2.22084\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound management & prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.25270/wmp.2023.2.22084","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 1
摘要
背景:糖尿病伤口(DW)是糖尿病的一种使人衰弱的并发症。虽然有多种治疗策略可用于DW的治疗,但由于DW的病理生理多方位,没有一种治疗策略能满足所有的基本要求。鉴于DW一直存在的威胁,新的改进的治疗策略和DW研究的加强应该得到更好的优先考虑。目的研究人β防御素-2 (HBD-2)在皮肤创面中的作用,为DW治疗提供参考。方法在Scopus、Web of Science、PubMed、谷歌Scholar和Clinical Trials英文论文数据库中检索相关摘要、研究综述文章和专利。结果shbd -2是一种保护人体免受感染的重要先天免疫反应蛋白。最近的报道也支持HBD-2在抑制炎症、促进增殖和血管生成方面的作用。根据文献,它的治疗管理已被提出维持DW的系统稳态平衡。结论HBD-2可能是一种重要的调节因子,通过促进细胞增殖和血管生成来控制慢性炎症和大小,为DW的治疗开辟了新的选择。
Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.
BACKGROUND
Diabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.
PURPOSE
The current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.
METHODS
This review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.
RESULTS
HBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.
CONCLUSION
It has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.