性激素结合球蛋白基因多态性对前列腺癌患者血清SHBG水平的影响

IF 0.8 Q4 GENETICS & HEREDITY
Zahra Tahmasebi Fard
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引用次数: 0

摘要

为了评估前列腺癌与三个编码区多态性(rs6257, rs6258, rs6259)的可能相关性;前列腺特异性抗原浓度和SHBG水平对SHBG基因启动子TAAAA重复序列的影响。为了研究目的,总共招募了352名受试者(176名患者和176名对照组)。采用ELISA技术和RFLP-PCR方法。基因型Logistic回归和校正回归分析结果显示,携带TAAAA五核苷酸序列超过5个重复的个体,以及携带AA+AG (rs6257)和AA+AG (rs6259)的个体,TAAAA n多态性增加前列腺癌风险的机会比分别为1.622、2.005和2.469。所研究的多态性与疾病分期和Gleason评分有显著关系。携带突变基因的个体比携带野生基因型的个体患前列腺癌的可能性要小。癌症组各基因型患者血清tPSA和fPSA水平均高于对照组。观察到显著的相关性(除了tPSA和fPSA对GT (rs6258)和fPSA对GA (rs6259))。Panta TAAAA (TAAAA)n、GG (rs6257)、TT和TT + CT (rs6258)、GG、AA和AA+GA (rs6259)基因型患者血清SHBG水平与前列腺癌也有显著相关性。这些多态性通过改变血清SHBG水平导致前列腺癌的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of sex hormone-binding globulin gene polymorphisms on the serum level of SHBG hormone in the men with prostate cancer

To evaluated the possible correlations of prostate cancer and three coding region polymorphisms (rs 6257, rs6258, rs 6259), & changing repeat of TAAAA in promoter of SHBG gene regarding to concentration of Prostate specific Antigen and SHBG levels. For study purpose, a total of 352 subjects (176 patients and 176 controls) were recruited. The ELISA technique and the RFLP-PCR method were used. Logistic and adjusted regression of genotypes showed that the (TAAAA)n polymorphism in individuals carrying more than five repeats of the five-nucleotide sequence of TAAAA, as well as AA+AG (rs6257) and AA+AG (rs6259), increased the risk of prostate cancer by the chance ratio of 1.622, 2.005, and 2.469, respectively. The studied polymorphisms showed a significant relationship with the stage of the disease and Gleason score. The individuals carrying the mutants were less likely to develop prostate cancer than the ones with wild genotypes. All the genotypes in the cancer group had higher serum levels of tPSA and fPSA than those in the control group. A significant association was observed (except tPSA and fPSA for GT (rs6258) and fPSA for GA (rs6259)). Serum level of SHBG also showed a significant correlation with prostate cancer in genotypes >Panta TAAAA (TAAAA)n, GG (rs6257), TT and TT + CT (rs6258), and GG, AA, and AA+GA (rs6259). These polymorphisms by changing the serum levels SHBG contributed to the incidence of prostate cancer.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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