盐酸昂丹司琼味觉掩蔽快溶片的固体分散处方及评价

Q3 Pharmacology, Toxicology and Pharmaceutics
Alaa A. Abdulqader, Eman B. H. Al-Khedairy
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引用次数: 7

摘要

盐酸昂丹司琼(ONH)是一种非常苦、强效的止吐药物,用于治疗和/或预防化疗、放疗或术后诱发的呕吐。本研究的目的是配制和评价ONH的味觉掩蔽快溶片(FDTs),以提高患者的依从性。以Eudragit E100聚合物为惰性载体,采用固体分散技术制备了ONH味觉掩蔽颗粒。溶剂蒸发法和熔融法用于这种制备。从溶剂蒸发法制备的颗粒中,采用药物与聚合物的比例为1:2,在pH 6.8的磷酸盐缓冲液中获得药物零释放的完全味觉掩蔽,其中四个配方通过预压缩评估并压缩到FDTs中,评估其药物含量、体外崩解时间、体内崩解时间,润湿时间和体外药物释放曲线。F7是由相当于所需剂量的ONH的固体分散体产物制备的,交联聚维酮作为超级崩解剂,阿斯巴甜作为甜味剂,罗斯浆果作为香料,聚乙烯吡咯烷酮K30.3.a作为粘合剂,Avicil PH102和甘露醇作为稀释剂,提供了最佳的体外、体内崩解时间和最佳的药物释放特性。关键词:盐酸昂丹司琼,味觉掩蔽,固体分散体,优德拉吉E100。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation and Evaluation of Fast Dissolving Tablets of Taste-Masked Ondansetron Hydrochloride by Solid Dispersion
Ondansetron hydrochloride (ONH) is a very bitter, potent antiemetic drug used for the treatment and/or prophylaxis of chemotherapy or radiotherapy or postoperative induced emesis. The objective of this study is to formulate and evaluate of taste masked fast dissolving tablet (FDTs) of ONH to increase patient compliance.  ONH taste masked granules were prepared by solid dispersion technique using Eudragit E100 polymer as an inert carrier. Solvent evaporation and fusion melting methods were used for such preparation. Completely taste masking with zero release of drug in phosphate buffer pH 6.8was obtained from granules prepared by solvent evaporation method using drug: polymer ratio of 1:2, from which four formulas pass pre-compression evaluation and compressed to FDTs and evaluated for their drug content, in-vitro disintegration time, in-vivo disintegration time, wetting time and in vitro drug release profile. F7 which is prepared from solid dispersion product equivalent to the required dose of ONH  , Crosspovidone as superdisintegrant, Aspartame as sweetener ,Ross berry as flavor ,Polyvinylpyrolidone K30.3.as binder ,Avicil PH102 and , mannitol as diluents give best in- vitro, in-vivo disintegration time and best drug release profile. Key words: Ondansetron hydrochloride, taste masking, solid dispersion, Eudragit E100.
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来源期刊
Iraqi Journal of Pharmaceutical Sciences
Iraqi Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
37
审稿时长
24 weeks
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