大疱性类天疱疮1例与血清抗BP180 - NC16a抗体和胸腺及激活调节趋化因子水平相关

IF 1.1 Q4 ALLERGY
Satoko Minakawa MD, PhD, Yasushi Matsuzaki MD, PhD, Atsuko Kimura MD, Kageaki Taima MD, PhD, Sadatomo Tasaka MD, PhD, Daisuke Sawamura MD, PhD
{"title":"大疱性类天疱疮1例与血清抗BP180 - NC16a抗体和胸腺及激活调节趋化因子水平相关","authors":"Satoko Minakawa MD, PhD,&nbsp;Yasushi Matsuzaki MD, PhD,&nbsp;Atsuko Kimura MD,&nbsp;Kageaki Taima MD, PhD,&nbsp;Sadatomo Tasaka MD, PhD,&nbsp;Daisuke Sawamura MD, PhD","doi":"10.1002/cia2.12310","DOIUrl":null,"url":null,"abstract":"<p>Our cases suggest that thymus and activation-regulated chemokine (TARC) levels are correlated with bullous pemphigoid (BP) disease area index for skin uriticaria/erythema, and serum anti-BP180-NC16a antibody titers in patients with BP. TARC might be an important chemokine involved in the pathogenesis of BP (<i>Br J Dermatol</i> 2003;148:203; <i>J Eur Acad Dermatol Venereol</i> 2021;35:e121). We speculate that TARC is useful for predicting the clinical condition of patients with BP, similar to anti-BP180-NC16a antibody titers.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12310","citationCount":"0","resultStr":"{\"title\":\"A case of bullous pemphigoid with correlation to serum levels of anti-BP180-NC16a antibodies and thymus and activation-regulated chemokine\",\"authors\":\"Satoko Minakawa MD, PhD,&nbsp;Yasushi Matsuzaki MD, PhD,&nbsp;Atsuko Kimura MD,&nbsp;Kageaki Taima MD, PhD,&nbsp;Sadatomo Tasaka MD, PhD,&nbsp;Daisuke Sawamura MD, PhD\",\"doi\":\"10.1002/cia2.12310\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Our cases suggest that thymus and activation-regulated chemokine (TARC) levels are correlated with bullous pemphigoid (BP) disease area index for skin uriticaria/erythema, and serum anti-BP180-NC16a antibody titers in patients with BP. TARC might be an important chemokine involved in the pathogenesis of BP (<i>Br J Dermatol</i> 2003;148:203; <i>J Eur Acad Dermatol Venereol</i> 2021;35:e121). We speculate that TARC is useful for predicting the clinical condition of patients with BP, similar to anti-BP180-NC16a antibody titers.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":15543,\"journal\":{\"name\":\"Journal of Cutaneous Immunology and Allergy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12310\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cutaneous Immunology and Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cia2.12310\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Immunology and Allergy","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cia2.12310","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0

摘要

大疱性类天疱疮(BP)是一种自身免疫性起泡疾病,其特征是表皮下起泡和皮肤糜烂病变BP患者在表皮基底膜区产生针对BP180的NC16a结构域的自身抗体1,2。我们报告了一例BP与血清中抗bp180nc16a抗体和胸腺及激活调节趋化因子(TARC/CCL17)水平的相关性。病例1,一名85岁的日本女性,有5个月的红斑和瘙痒史,对局部类固醇治疗有耐药性。她有高血压和潜伏结核感染。体格检查显示身体、上臂、腿部和背部有红斑、糜烂和水疱(图1A - D)。皮肤水泡/糜烂的BP疾病面积指数(BPDAI)为34;皮肤荨麻疹/红斑的BPDAI为25。实验室检查结果如下(正常范围):白细胞计数:5570/μL (3300 ~ 8600 /μL);嗜酸性粒细胞4.7% (0.4% - 8.6%);乳酸脱氢酶(LD), 243 U/L (124 ~ 222 U/L);活性蛋白(CRP), 0.08 mg/dL (0.00 - 0.14 mg/dL);总免疫球蛋白E (IgE)为133.0 IU/mL (0 ~ 232 IU/mL)。血清抗bp180nc16a抗体滴度159.5 U/mL (0 ~ 8.9 U/mL), TARC水平升高1031 pg/mL (0 ~ 450 pg/mL)。右背部活检标本显示表皮下水疱(图1E,F)。直接免疫荧光显示IgG和C3c在表皮基底膜区呈线性沉积(图1G,H)。诊断为BP。开始口服强的松龙0.5 mg/kg/天可减轻皮肤症状。3个月后,BPDAI清晰,实验室检查结果有所改善:白细胞计数10,920/μL;嗜酸性粒细胞,0.2%;Ld, 293 u / l;CRP, 0.05 mg/dL;总IgE 14.9 IU/mL;抗bp180nc16a抗体滴度,4.7 U/mL;TARC, 120 pg/mL。为了探讨抗bp180nc16a抗体滴度与其他实验室数据的相关性,我们对7例到广明大学医院就诊的BP患者进行了评估。实验室数据从口服强的松龙治疗前的医疗记录中检索。根据临床、病理及免疫荧光特征诊断为BP。该研究已获得弘崎大学医学研究生院医学伦理委员会批准(No. 2021025)。在262例BP或可能BP患者中,检测TARC和抗bp180抗体(NC16a), 7例患者的抗bp180抗体(NC16a)呈阳性(图1I)。抗bp180nc16a抗体滴度平均为8990.61 U/mL,治疗3个月后抗体滴度提高至124.81 U/mL。平均TARC为4202.14 pg/mL,治疗3个月后改善为267 pg/mL。由于病例数少,我们无法显示统计学意义;治疗后,抗bp180nc16a抗体滴度和TARC平均值均下降。BP疾病活动性与抗bp180nc16a抗体滴度之间的相关性是众所周知的。BP与TARC之间的关系已有报道。3,4因此,TARC可能是参与BP发病的重要趋化因子。3,4我们推测TARC与抗bp180nc16a抗体滴度类似,可用于预测BP患者的临床状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A case of bullous pemphigoid with correlation to serum levels of anti-BP180-NC16a antibodies and thymus and activation-regulated chemokine

A case of bullous pemphigoid with correlation to serum levels of anti-BP180-NC16a antibodies and thymus and activation-regulated chemokine

Our cases suggest that thymus and activation-regulated chemokine (TARC) levels are correlated with bullous pemphigoid (BP) disease area index for skin uriticaria/erythema, and serum anti-BP180-NC16a antibody titers in patients with BP. TARC might be an important chemokine involved in the pathogenesis of BP (Br J Dermatol 2003;148:203; J Eur Acad Dermatol Venereol 2021;35:e121). We speculate that TARC is useful for predicting the clinical condition of patients with BP, similar to anti-BP180-NC16a antibody titers.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信