基于DNA生物传感器的被忽视热带疾病检测：迈向智能诊断

IF 1.6 4区工程技术 Q3 INSTRUMENTS & INSTRUMENTATION

Sensor Review Pub Date : 2022-07-21 DOI:10.1108/sr-11-2021-0429

B. J. Stephen, Surabhi Suchanti, Devendra Jain, Harshdeep Dhaliwal, Vikram Sharma, Ramandeep Kaur, Rajeev Mishra, Abhijeet Singh

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引用次数: 0

摘要

被忽视的热带病(NTDs)是主要影响赤道附近低收入国家的一系列传染病。有效的诊断工具是遏制这些传染病蔓延的关键。然而，特异性是与当前诊断方案相关的主要问题。在这方面，电化学脱氧核糖核酸(DNA)生物传感器可以发挥至关重要的作用，正如对其研究的新兴趣所强调的那样。本研究的目的是强调用于检测NTDs相关病原体的生物传感器的设计和开发的现状。这篇综述强调了不同类型的因素和用于增强传感器性能的修改。通过对现有文献的回顾，作者讨论了电化学DNA生物传感器作为检测与被忽视热带病相关病原体的高效、负担得起的诊断工具的潜力。本研究讨论了生物传感器的组成，主要是探针的选择和电极的类型，以及它们对生物传感器整体设计的改进潜力。此外，本研究还分析了ntd电化学DNA生物传感器中使用的不同纳米材料，并讨论了它们的加入如何提高生物传感器设计的整体灵敏度和特异性。最后，本研究探讨了这些技术在未来大规模筛查被忽视热带病方面可能产生的影响。研究结果为电化学DNA生物传感器检测与ntd相关的病原体提供了深入的分析。原创性/价值本文综述了用于诊断ntd相关病原体的不同类型和修改的DNA生物传感器的最新进展。

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DNA biosensor based detection for neglected tropical disease: moving towards smart diagnosis

Purpose Neglected tropical diseases (NTDs) are a set of infectious diseases that primarily affect low-income countries situated near the equator. Effective diagnostic tools hold the key to stemming the spread of these infectious diseases. However, specificity is a major concern associated with current diagnostic protocols. In this regard, electrochemical deoxyribonucleic acid (DNA) biosensors could play a crucial role, as highlighted by renewed interest in their research. The purpose of this study was to highlight the current scenario for the design and development of biosensors for the detection of NTDs related pathogens. This review highlights the different types of factors involved and the modifications used to enhance sensor properties. Design/methodology/approach The authors discuss the potential of electrochemical DNA biosensors as efficient, affordable diagnostic tools for the detection of pathogens associated with NTDs by reviewing available literature. This study discusses the biosensor components, mainly the probe selection and type of electrodes used, and their potential to improve the overall design of the biosensor. Further, this study analyses the different nanomaterials used in NTD-based electrochemical DNA biosensors and discusses how their incorporation could improve the overall sensitivity and specificity of the biosensor design. Finally, this study examines the impact such techniques could have in the future on mass screening of NTDs. Findings The findings provide an in-depth analysis of electrochemical DNA biosensors for the detection of pathogens associated with NTDs. Originality/value This review provides an update on the different types and modifications of DNA biosensors that have been designed for the diagnosis of NTD-related pathogens.

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来源期刊

Sensor Review 工程技术-仪器仪表

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

3.7 months

期刊介绍： Sensor Review publishes peer reviewed state-of-the-art articles and specially commissioned technology reviews. Each issue of this multidisciplinary journal includes high quality original content covering all aspects of sensors and their applications, and reflecting the most interesting and strategically important research and development activities from around the world. Because of this, readers can stay at the very forefront of high technology sensor developments. Emphasis is placed on detailed independent regular and review articles identifying the full range of sensors currently available for specific applications, as well as highlighting those areas of technology showing great potential for the future. The journal encourages authors to consider the practical and social implications of their articles. All articles undergo a rigorous double-blind peer review process which involves an initial assessment of suitability of an article for the journal followed by sending it to, at least two reviewers in the field if deemed suitable. Sensor Review’s coverage includes, but is not restricted to: Mechanical sensors – position, displacement, proximity, velocity, acceleration, vibration, force, torque, pressure, and flow sensors Electric and magnetic sensors – resistance, inductive, capacitive, piezoelectric, eddy-current, electromagnetic, photoelectric, and thermoelectric sensors Temperature sensors, infrared sensors, humidity sensors Optical, electro-optical and fibre-optic sensors and systems, photonic sensors Biosensors, wearable and implantable sensors and systems, immunosensors Gas and chemical sensors and systems, polymer sensors Acoustic and ultrasonic sensors Haptic sensors and devices Smart and intelligent sensors and systems Nanosensors, NEMS, MEMS, and BioMEMS Quantum sensors Sensor systems: sensor data fusion, signals, processing and interfacing, signal conditioning.