产前皮质类固醇改善极早产儿围产期结局的研究进展

Q4 Medicine

中华围产医学杂志 Pub Date : 2019-12-16 DOI:10.3760/CMA.J.ISSN.1007-9408.2019.12.012

Siwei Luo

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引用次数: 0

摘要

在工业化国家不同时期进行的大规模人群队列研究显示，在20世纪90年代中期，极早产儿(EPT， <28孕周)的产前皮质类固醇使用率达到60%或更高，同时在发达国家，胎龄≥25周的EPT的围产期死亡率稳步下降至13%-22%。值得注意的是，自2005年以来，瑞典妊娠23-24周的EPT存活率超过50%。在过去的三十年中，产前皮质类固醇使用的增加与EPT死亡率的稳步下降之间存在联系。在中国目前的医疗背景下，需要高质量的证据来证明产前皮质类固醇对EPT围产儿结局的影响。本文综述了EPT产前皮质类固醇治疗的进展，以期促进中国母婴保健质量的提高。关键词:糖皮质激素;婴儿，极度早产儿;Peripartum时期;预后

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Advances in antenatal corticosteroids for improving perinatal outcomes of extremely preterm infants

Large population-based cohort studies conducted in the industrialized countries in different eras revealed that the use of antenatal corticosteroids for extremely preterm births (EPT, <28 gestational weeks) reached 60% or higher in the mid-1990s, accompanying by steadily declined perinatal mortality to 13%-22% in EPT with gestational age ≥25 weeks in developed countries. Notably, the survival rate of EPT with 23-24 weeks of gestation was over 50% in Sweden since 2005. There's a link between the increment of antenatal corticosteroids use and steady decline of mortality in EPT in the past three decades. High-quality evidence is needed to demonstrate the impact of antenatal corticosteroids on EPT perinatal outcomes under the current healthcare background in China. This review, focusing on the progression of antenatal corticosteroid treatment for EPT, may facilitate the quality improvement of maternal-fetal and infant healthcare in China. Key words: Glucocorticoids; Infant, extremely premature; Peripartum period; Prognosis

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来源期刊

中华围产医学杂志 Medicine-Obstetrics and Gynecology

CiteScore

0.70

自引率

0.00%

发文量

4446

期刊介绍： Chinese Journal of Perinatal Medicine was founded in May 1998. It is one of the journals of the Chinese Medical Association, which is supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by Peking University First Hospital. Perinatal medicine is a new discipline jointly studied by obstetrics and neonatology. The purpose of this journal is to "prenatal and postnatal care, improve the quality of the newborn population, and ensure the safety and health of mothers and infants". It reflects the new theories, new technologies, and new progress in perinatal medicine in related disciplines such as basic, clinical and preventive medicine, genetics, and sociology. It aims to provide a window and platform for academic exchanges, information transmission, and understanding of the development trends of domestic and foreign perinatal medicine for the majority of perinatal medicine workers in my country.