真核生物b家族复制酶与核糖核苷酸的结合及其对基因组稳定性的影响。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2022-02-14 DOI:10.1146/annurev-biochem-032620-110354

Jessica S. Williams, T. Kunkel

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引用次数: 6

摘要

随着DNA中核糖核苷酸存在的新细节的出现，我们目前对基于DNA的基因组如何有效和准确地复制的看法继续发展。核糖核苷酸在真核生物DNA复制过程中被整合，其速率使其成为核基因组中最常见的非规范核苷酸，它们被有效修复，并且它们的移除影响基因组的完整性。本文综述了这一主题的三个方面:核糖核苷酸在b家族DNA复制酶复制过程中融入真核生物核基因组，这些核糖核苷酸如何被去除，以及它们的存在或去除对基因组稳定性和疾病的影响。预计《生物化学年度评论》91卷的最终在线出版日期为2022年6月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ribonucleotide Incorporation by Eukaryotic B-family Replicases and Its Implications for Genome Stability.

Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.