胺碘酮治疗致药物性肝损伤短期肝硬化1例

Q4 Medicine
Hikari Kobayashi, H. Nagai, T. Mukozu, Kunihide Mori, Gou Watanabe, Naoyuki Yoshimine, Kojiro Kobayashi, Y. Ogino, Teppei Matsui, Yasuko Daido, N. Wakui, Koichi Momiyama, Y. Igarashi
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引用次数: 1

摘要

患者是一位70多岁的老人,因老年性心肌梗死到我院心内科就诊;然而,在20XX年,由于心室颤动导致心脏骤停,植入了除颤器,并使用胺碘酮预防心律失常。患者因肝损伤服用胺碘酮1年8个月后转到我科就诊,腹部单纯CT检查显示肝脏高吸收。他被诊断为胺碘酮引起的药物性肝损伤,并被建议停药;然而,由于没有替代药物,药物管理仍在继续。在开始服用胺碘酮四年零一个月后,他被诊断出患有肝硬化,并停止服用。六个月后,他死于肝功能衰竭。由于胺碘酮引起的药物性肝损伤可迅速发展为肝硬化,因此监测血液中胺碘酮的水平并调整剂量是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case of drug-induced liver injury causing cirrhosis in the short term by the treatment of amiodarone
The patient was a man in his 70s who had been attending our hospitalʼs Department of Cardiology for an old myocardial infarction; however, in 20XX, a defibrillator was implanted due to cardiac arrest caused by ven-tricular fibrillation, and amiodarone was used to prevent arrhythmia. He was referred to our department 1 year and 8 months after taking amiodarone due to liver damage, and an abdominal simple CT examination showed high absorption of the liver. He was diagnosed with drug-induced liver injury due to amiodarone and was ad-vised to discontinue the drug; however, the drug administration was continued because there was no alterna-tive drug. He was diagnosed with cirrhosis four years and one month after starting amiodarone, and he stopped taking it. He died of liver failure six months later. Because amiodarone-induced drug-induced liver injury can quickly progress to cirrhosis, it is important to monitor blood levels of amiodarone and adjust the dose.
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来源期刊
Acta Hepatologica Japonica
Acta Hepatologica Japonica Medicine-Hepatology
CiteScore
0.10
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