Hikari Kobayashi, H. Nagai, T. Mukozu, Kunihide Mori, Gou Watanabe, Naoyuki Yoshimine, Kojiro Kobayashi, Y. Ogino, Teppei Matsui, Yasuko Daido, N. Wakui, Koichi Momiyama, Y. Igarashi
{"title":"胺碘酮治疗致药物性肝损伤短期肝硬化1例","authors":"Hikari Kobayashi, H. Nagai, T. Mukozu, Kunihide Mori, Gou Watanabe, Naoyuki Yoshimine, Kojiro Kobayashi, Y. Ogino, Teppei Matsui, Yasuko Daido, N. Wakui, Koichi Momiyama, Y. Igarashi","doi":"10.2957/kanzo.63.203","DOIUrl":null,"url":null,"abstract":"The patient was a man in his 70s who had been attending our hospitalʼs Department of Cardiology for an old myocardial infarction; however, in 20XX, a defibrillator was implanted due to cardiac arrest caused by ven-tricular fibrillation, and amiodarone was used to prevent arrhythmia. He was referred to our department 1 year and 8 months after taking amiodarone due to liver damage, and an abdominal simple CT examination showed high absorption of the liver. He was diagnosed with drug-induced liver injury due to amiodarone and was ad-vised to discontinue the drug; however, the drug administration was continued because there was no alterna-tive drug. He was diagnosed with cirrhosis four years and one month after starting amiodarone, and he stopped taking it. He died of liver failure six months later. Because amiodarone-induced drug-induced liver injury can quickly progress to cirrhosis, it is important to monitor blood levels of amiodarone and adjust the dose.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A case of drug-induced liver injury causing cirrhosis in the short term by the treatment of amiodarone\",\"authors\":\"Hikari Kobayashi, H. Nagai, T. Mukozu, Kunihide Mori, Gou Watanabe, Naoyuki Yoshimine, Kojiro Kobayashi, Y. Ogino, Teppei Matsui, Yasuko Daido, N. Wakui, Koichi Momiyama, Y. Igarashi\",\"doi\":\"10.2957/kanzo.63.203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The patient was a man in his 70s who had been attending our hospitalʼs Department of Cardiology for an old myocardial infarction; however, in 20XX, a defibrillator was implanted due to cardiac arrest caused by ven-tricular fibrillation, and amiodarone was used to prevent arrhythmia. He was referred to our department 1 year and 8 months after taking amiodarone due to liver damage, and an abdominal simple CT examination showed high absorption of the liver. He was diagnosed with drug-induced liver injury due to amiodarone and was ad-vised to discontinue the drug; however, the drug administration was continued because there was no alterna-tive drug. He was diagnosed with cirrhosis four years and one month after starting amiodarone, and he stopped taking it. He died of liver failure six months later. Because amiodarone-induced drug-induced liver injury can quickly progress to cirrhosis, it is important to monitor blood levels of amiodarone and adjust the dose.\",\"PeriodicalId\":35810,\"journal\":{\"name\":\"Acta Hepatologica Japonica\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Hepatologica Japonica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2957/kanzo.63.203\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Hepatologica Japonica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2957/kanzo.63.203","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
A case of drug-induced liver injury causing cirrhosis in the short term by the treatment of amiodarone
The patient was a man in his 70s who had been attending our hospitalʼs Department of Cardiology for an old myocardial infarction; however, in 20XX, a defibrillator was implanted due to cardiac arrest caused by ven-tricular fibrillation, and amiodarone was used to prevent arrhythmia. He was referred to our department 1 year and 8 months after taking amiodarone due to liver damage, and an abdominal simple CT examination showed high absorption of the liver. He was diagnosed with drug-induced liver injury due to amiodarone and was ad-vised to discontinue the drug; however, the drug administration was continued because there was no alterna-tive drug. He was diagnosed with cirrhosis four years and one month after starting amiodarone, and he stopped taking it. He died of liver failure six months later. Because amiodarone-induced drug-induced liver injury can quickly progress to cirrhosis, it is important to monitor blood levels of amiodarone and adjust the dose.