腹膜透析患者血清镁浓度相关的临床因素:一项单中心观察研究

IF 2.1 Q2 UROLOGY & NEPHROLOGY
S. Kaneko, S. Ookawara, Y. Morishita
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引用次数: 1

摘要

目的镁(Mg)是一种与各种生理功能有关的必需元素,如维持血压、肌肉收缩和神经功能。在接受血液透析的患者中,低镁血症与心血管和全因死亡率相关。然而,在接受腹膜透析(PD)的患者中,与镁相关的临床因素尚未得到充分研究。患者和方法从PD患者的病历中收集临床因素,包括人体测量数据、合并症、实验室数据、药物和透析方法。通过单变量和多变量分析研究这些因素与血清镁浓度的关系。结果对60例帕金森病患者进行了调查。单因素分析显示,血清镁浓度与混合PD治疗(每日PD+每周血液透析一次)(β=0.264,P=0.04)、磷酸盐结合剂给药(β=0.294,P=0.02)、血清C反应蛋白浓度(β=-0.318,P=0.01)、血清钾(K)浓度(β=0.451,P<0.01)、,和血清完整甲状旁腺激素浓度(β=−0.333,P=0.01)。利用这些因素进行的多变量分析显示,血清Mg和K浓度之间存在独立相关性(β=0..333,P=0.001)。结论PD患者血清Mg浓度与血清K浓度独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study
Purpose Magnesium (Mg) is an essential element that is associated with various physiological functions, such as maintenance of blood pressure, muscle contraction, and nerve function. In patients undergoing hemodialysis, hypomagnesemia is associated with cardiovascular and all-cause mortality. However, in patients undergoing peritoneal dialysis (PD), clinical factors associated with Mg have not been fully investigated. Patients and Methods Clinical factors including anthropometric data, comorbidities, laboratory data, medications, and dialysis methods were collected from the medical records of patients undergoing PD. The associations of these factors with the serum Mg concentration were investigated by univariate and multivariate analyses. Results Sixty patients undergoing PD were investigated. The univariate analysis showed that the serum Mg concentration was significantly associated with treatment by hybrid PD (daily PD + once-weekly hemodialysis) (β = 0.264, P = 0.04), administration of phosphate binders (β = 0.294, P = 0.02), the serum C-reactive protein concentration (β = −0.318, P = 0.01), the serum potassium (K) concentration (β = 0.451, P < 0.01), and the serum intact parathormone concentration (β = −0.333, P = 0.01). The multivariate analysis using these factors showed an independent association between the serum Mg and K concentrations (β = 0.333, P = 0.01). Conclusion The serum Mg concentration was independently associated with the serum K concentration in patients undergoing PD.
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来源期刊
CiteScore
3.90
自引率
5.00%
发文量
40
审稿时长
16 weeks
期刊介绍: International Journal of Nephrology and Renovascular Disease is an international, peer-reviewed, open-access journal focusing on the pathophysiology of the kidney and vascular supply. Epidemiology, screening, diagnosis, and treatment interventions are covered as well as basic science, biochemical and immunological studies. In particular, emphasis will be given to: -Chronic kidney disease- Complications of renovascular disease- Imaging techniques- Renal hypertension- Renal cancer- Treatment including pharmacological and transplantation- Dialysis and treatment of complications of dialysis and renal disease- Quality of Life- Patient satisfaction and preference- Health economic evaluations. The journal welcomes submitted papers covering original research, basic science, clinical studies, reviews & evaluations, guidelines, expert opinion and commentary, case reports and extended reports. The main focus of the journal will be to publish research and clinical results in humans but preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies and interventions.
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