表型相互作用中的上皮-间充质可塑性参与干性。

Q1 Biochemistry, Genetics and Molecular Biology
V. Chin, C. Lim
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引用次数: 25

摘要

癌症是一种遗传性疾病,导致肿瘤抑制信号和致癌信号之间的功能失衡。世界卫生组织强调了这种顽固性疾病的负担,将其列为全球第二大死亡原因。癌症相关死亡的主要原因很少是原发肿瘤本身的影响,而是癌细胞在转移中毁灭性的扩散。上皮-间充质可塑性(Epithelial-mesenchymal plasticity, EMP)是指细胞在上皮-间充质转化(Epithelial-mesenchymal transition, EMT)和间充质-上皮转化(mesenchymal-epithelial transition, MET)状态之间维持其可塑性和转移的能力,在癌症转移中起着重要作用。这些细胞转移允许它们从原发肿瘤转移到继发肿瘤。EMP与迁移、入侵、殖民化、自我更新和耐药性有关。本文就EMP的机制、肿瘤干细胞(CSCs)和循环肿瘤细胞(ctc)之间的关系、EMP中涉及的生物标志物和信号通路、耐药和靶向治疗等方面进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epithelial-mesenchymal plasticity-engaging stemness in an interplay of phenotypes.
Cancer is a genetic disease which results in a functional imbalance between tumour-repressive and oncogenic signals. The WHO highlights the burden of this indomitable disease, listing it as the second leading cause of death globally. The major cause of cancer-related death is rarely the effect of the primary tumour itself, but rather, the devastating spread of cancer cells in metastases. Epithelial-mesenchymal plasticity (EMP)-termed as the ability of cells to maintain its plasticity and transit between epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states-plays a fundamental role in cancer metastasis. These cell transitions allow them migrate from the primary tumour and invade the secondary site. EMP is associated with migration, invasion, colonisation, self-renewal and drug resistance. This review briefly elucidates the mechanism of EMP and the association between cancer stem cells (CSCs) and circulating tumour cells (CTCs), biomarkers and signalling pathways involved in EMP as well as drug resistance and therapeutic targeting.
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来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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