樱草酸1对一种水蚤的毒性研究。

European Pharmaceutical Journal Pub Date : 2020-05-01 DOI:10.2478/afpuc-2020-0013

M. Lukáč, M. Pisárčik, R. Horáková, M. Bajcura, B. Horváth, F. Devínsky

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引用次数: 0

摘要

摘要报春花中的主要皂苷为Primulic acid 1。本研究描述了从报春花根中分离这种两亲性化合物。采用超声波浸渍、反相柱色谱和结晶等方法对其进行了表征。其物理化学性质的研究以临界胶束浓度（cmc）的测定为代表。两亲物的cmc值为9.4×10−5mol·dm−3。对一种对原始酸1非常敏感的水蚤进行了环境毒性评估。急性固定化试验的结果表明，受试化合物在24小时后（EC50-24小时）具有一半的最大有效浓度，等于6.9 mg·l−1。皂苷可被归类为对水生生物有毒的化合物。

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Toxicity of primulic acid 1 against a daphnid species Simocephalus expinosus s.l.

Abstract Primulic acid 1 is the main saponin present in Primula elatior. The present study describes the isolation of this amphiphilic compound from primula root. It was performed by ultrasonic maceration, reverse-phase column chromatography and crystallization. Investigations of its physicochemical property are represented by the determination of critical micelle concentration (cmc). The cmc value of the amphiphile was 9.4 × 10−5 mol·dm−3. The evaluation of environmental toxicity was performed on a daphnid species Simpocephalus expinosus s.l., which was very sensitive to primulic acids 1. The results from acute immobilisation test show that the tested compound has half maximal effective concentration after 24 hours (EC50-24 h) equal to 6.9 mg·l−1. Saponin can be classified as a toxic compound for aquatic organisms.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.