邻苯二甲酸二(2-乙基己基)酯对鲤鱼某些血液学和组织学参数的影响

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2022-07-15 DOI:10.18311/ti/2022/v29i2/29129

K. Bisai, Bijay Kumar Behera, Sukanta Kumar Nayak, Manoj Kumar Pati

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引用次数: 0

摘要

邻苯二甲酸二(2-乙基己基)酯(DEHP)是水生环境中常见的增塑剂，因为塑料被广泛用于各种用途。本研究以体长14.2±0.82 cm、体重32.8±0.66 g的鲤鱼(Cyprinus carpio)为研究对象，在10、100和1000 μ g l-1水中分别暴露DEHP 30 d，观察其对某些血液学和组织学参数的影响。血液学研究显示，随着DEHP浓度的升高，治疗组红细胞计数显著减少(p<0.05)，白细胞计数显著增加(p<0.05)。此外，DEHP以浓度依赖的方式处理显示红细胞畸形，而白细胞未受影响。血浆总蛋白水平随暴露浓度的升高而显著降低(p<0.05)。组织学研究显示，鳃和肝组织受影响，组织结构受损呈剂量依赖性。

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Effect of Di-(2-Ethylhexyl) Phthalate on Certain Haematological and Histological Parameters of Common Carp (Cyprinus carpio)

Di-(2-Ethyl-Hexyl) Phthalate (DEHP) is a plasticizer commonly found in aquatic environment due to wide use of plastics for various purposes. In this study, common carp (Cyprinus carpio) (length 14.2 ± 0.82 cm and weight 32.8 ± 0.66 g) were exposed to DEHP at three different concentration levels i.e., 10, 100 and 1000 ?g l-1 water for 30 d to find out its effect on certain haematological and histological parameters. Haematological studies revealed significant (p<0.05) decrease in erythrocyte counts, while leukocyte counts were significantly increased in treated group with increasing concentration of DEHP. Further, treatment of DEHP in concentration dependent manner showed deformities in erythrocytes whereas leukocytes were unaffected. The total plasma protein level was significantly (p<0.05) decreased in lower to higher concentration of the exposure. Histological studies showed gill and liver tissues were affected with impaired histoarchitecture in a dose dependent manner.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.