功能精确图谱：个性化医学的前进之路

Journal of clinical haematology Pub Date : 2021-10-10 DOI:10.33696/haematology.2.031

Lyndsey Flanagan, S. Glavey, T. Chonghaile

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引用次数: 0

摘要

AML：急性髓细胞白血病；BAD:Bcl-2相关的细胞死亡激动剂；BAK：Bcl-2同源拮抗剂杀手；BAX：Bcl-2相关的X蛋白；Bcl-2:B细胞淋巴瘤2例；Bcl-W:B细胞淋巴瘤-W；Bcl-xL:B细胞淋巴瘤；Bfl-1:Bcl2相关基因在胎儿肝脏中表达；BH：Bcl-2同源性；BIK：Bcl-2相互作用的杀手；BIM：Bcl-2样蛋白11；BMF:Bcl-2修饰因子；CCND1:Cyclin D1；CD：分化簇；慢性淋巴细胞白血病；美国食品药品监督管理局；HRK：哈拉基里；JC-1：形成阳离子染料的第一个J聚集物；Mcl-1:Myeloid cell leukemia 1；MM：多发性骨髓瘤；MOMP：线粒体外膜渗透；NOXA：拉丁语，表示损害；PCL：浆细胞白血病；PUMA:p53上调调节剂；sPCL：继发性浆细胞白血病；tBID：截短的BH3相互作用结构域死亡激动剂

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Functional Precision Profiling: The Way Forward for Personalized Medicine

AML: Acute Myeloid Leukemia; BAD: Bcl-2 associated agonist of cell death; BAK: Bcl-2 homologous antagonist killer; BAX: Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; Bcl-W: B-cell lymphoma-w; Bcl-xL: B-cell lymphoma-extra-large; Bfl-1: Bcl-2-related gene expressed in fetal liver; BH: Bcl-2 Homology; BIK: Bcl-2 Interacting Killer; BIM: Bcl-2-like protein 11; BMF: Bcl-2 Modifying Factor; CCND1: Cyclin D1; CD: Cluster of Differentiation; CLL: Chronic Lymphocytic Leukemia; FDA: Food and Drug Administration; HRK: Harakiri; JC-1: 1st J-aggregateforming cationic dye; Mcl-1: Myeloid cell leukemia 1; MM: Multiple Myeloma; MOMP: Mitochondrial Outer Membrane Permeabilization; NOXA: Latin for damage; PCL: Plasma Cell Leukemia; PUMA: p53 Upregulated Modulator; sPCL: Secondary Plasma Cell Leukemia; tBID: Truncated BH3 interacting-domain death agonist

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Journal of clinical haematology

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