口服营养补充剂对胃大肠癌癌症出院后患者体重和生活质量的影响：一项前瞻性随机对照临床试验

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-10-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.05.002

Yi Jiang, Q. Meng, Shanjun Tan, Qi Zhang, Zhen Yu, Xinping Zhang

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引用次数: 0

摘要

目的探讨口服营养补充剂（ONS）对癌症患者出院后体重减轻和生活质量的影响。方法所有入选的癌症术后患者随机分为ONS组和对照组。出院后3个月测量体重减轻、中臂围、三头肌皮褶厚度和右手握力，并计算Karnofsky评分、ECOG评分和QOL评分。结果自出院2个月以来，ONS组癌症患者的体重减轻明显低于对照组。（出院后2个月：1.65±2.11vs.270±1.90kg，t=-2.3853，P=0.019 3；出院后3个月：1.95±2.75vs3.67±2.29kg，t=-3.1347，P=0.002 4），癌症患者两组体重减轻无差异。癌症组和结直肠癌组的中臂围、三角肌皮褶厚度和右手握力无统计学差异。癌症患者的Karnofsky评分（56.82±13.65%对51.71±9.72%，t=2.014 8，P=0.047 2）和QOL评分（41.91±6.92对38.39±8.77，t=2.059 7，P=0.042 6）高于对照组。而癌症患者的3种评分在两组之间没有差异。结论ONS能有效地减轻癌症患者出院后的体重减轻，改善患者的工作状态和生活质量，但对癌症患者无效。关键词：口服营养补充剂；胃恶性肿瘤；结肠恶性肿瘤

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Effects of oral nutritional supplements on body weight and life qualityin post-discharge patients with gastricor colorectal cancer: A prospective randomized controlled clinical trial

Objective To investigate the effect of oral nutritional supplements(ONS) on body weight loss and life quality in post-discharge patients with gastric and colorectal cancer. Methods All the enrolled post-operative gastric or colorectal cancer patients were randomly divided into ONS group and control group. Body weight loss, middle arm circumference, triceps skinfold thickness and right-hand grip strength were measured and the Karnofsky score, ECOG score and QOL score were calculated 3 months after the discharge. Results The body weight loss of gastric cancer patients was lower in ONS group than in control group since 2 months after discharge.(2 months after discharge: 1.65±2.11vs. 2.70±1.90 kg, t=-2.385 3, P=0.019 3; 3 months after discharge: 1.95±2.75vs. 3.67±2.29 kg, t=-3.134 7, P=0.002 4), There was no difference of body weight loss between two groups in colorectal cancer patients. The middle arm circumference, triceps skinfold thicknessand right-hand grip strength showed no statistic difference between two groups both in gastric and colorectal cancer patients. The Karnofsky score(56.82±13.65%vs. 51.71±9.72%, t=2.014 8, P=0.047 2) and QOL score(41.91±6.92 vs. 38.39±8.77, t=2.059 7, P=0.042 6) were higher in ONS group than in control group in gastric cancer patients. While all 3 types of scores had no difference between two groups in colorectal cancer patients. Conclusion ONS can efficiently reduce the body weight loss and improve the performance status and life qualityin post-discharge gastric cancer patients, but not in colorectal cancer patients. Key words: Oral nutritional supplement; Gastric malignancy; Colorectal malignancy

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.