静电纺丝控制纤维沉积和最大孔径技术综述

Kevin P. Feltz, Emily A. Growney Kalaf, Chengpeng Chen, R. Scott Martin, Scott A. Sell
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引用次数: 53

摘要

静电纺丝作为一种制备纳米纤维的技术已经被组织工程界和再生医学界广泛接受了几十年。由于静电纺丝工艺固有的灵活性,许多技术可以很容易地实现来控制纤维沉积(即电场/磁场操纵,使用交流电,或空气基纤维聚焦)和/或孔隙度(即空气阻抗,牺牲孔隙/牺牲纤维掺入,冷冻静电纺丝,或替代技术)。本文综述了近年来利用这些技术制备适合于模拟天然细胞外基质结构的静电纺丝支架的一些研究进展,以提高先进的静电纺丝技术在组织工程领域的适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size
Abstract Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/ magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.
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