口服4′-去甲基皂素可抑制皮肤干燥引起的机械变形

Itch (Philadelphia, Pa.) Pub Date : 2023-07-01 DOI:10.1097/itx.0000000000000069

S. Toyama, M. Tominaga, E. Komiya, S. Kusano, T. Kaneko, K. Takamori

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引用次数: 0

摘要

皮肤干燥会导致机械性异病，降低患者的生活质量。Nobiletin（NOB）是一种主要的柑橘类黄酮，具有多种健康益处。我们在小鼠模型中研究了口服NOB或4’-去甲基NOB是否抑制干燥皮肤诱导的同种异体病。结果，这两种治疗方法都能有效抑制机械性异速症。这些化合物可能是开发用于机械性异症的治疗剂的有希望的候选者。

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Oral administration of 4′-demethyl nobiletin inhibits dry skin-induced mechanical alloknesis

Mechanical alloknesis develops with dry skin and reduces the quality of life of people afflicted. Nobiletin (NOB) is a major citrus flavonoid with various health benefits. We investigated whether oral administration of NOB or 4’-demethyl NOB inhibits dry skin-induced alloknesis in a mouse model. As a result, both treatments were effective to inhibit mechanical alloknesis. These compounds may be promising candidates to lead to the development of therapeutic agents for mechanical alloknesis.

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Itch (Philadelphia, Pa.)

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