尼日利亚儿童对白喉、百日咳、破伤风(DPT)和五价疫苗的百日咳抗体反应比较

E. Ekanem, G. Bassey, H. Okpara, Eyong Komomo Ibor
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引用次数: 0

摘要

背景:自2012年以来,在尼日利亚,五价疫苗已取代白喉-百日咳-破伤风疫苗预防百日咳。目的和目的:本研究的目的是比较接受百白破和五价疫苗的儿童的抗百日咳免疫球蛋白G(IgG)反应。受试者和方法:本研究于2016年4月至6月在克罗斯河州的Akpabuyo LGA进行。这是一项对6个月至5岁接受百白破和五价疫苗接种的儿童抗百日咳IgG水平的横断面调查。使用酶联免疫吸附测定法测定IgG抗体水平。根据制造商的截止点,保护级别设置为>11 DU。结果:230名接种过百白破的儿童中有78名[33.9%]具有抗百日咳IgG的保护水平,而192名接种过五价疫苗的儿童中只有74名[38.5%]具有保护水平。差异无统计学意义[p=0.61]。接受DPT的患者的IgG抗体水平中位数为8.0 DU(四分位间距(IQR)4.0-13.0),而接受五价疫苗的患者为9.0 DU(IQR,4.0-15.0)[p=0.18]。在多变量分析中,所调查的单因素均未预测抗体保护水平的发展。结论/建议:百白破和五价疫苗接种者的抗百日咳抗体反应没有差异。需要进一步的研究来阐明可能导致该人群抗百日咳抗体反应低的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Pertussis Antibody Response of Nigerian Children to Diphtheria, Pertussis, Tetanus (DPT) and Pentavalent Vaccines
Background: In Nigeria Pentavalent vaccine had replaced Diphtheria-Pertussis- Tetanus [DPT] vaccine in the prevention of pertussis since 2012. Aims and Objectives: The aim of this study was to compare the anti-pertussis immunoglobin G (IgG) response of children who received DPT with those who received the pentavalent vaccine. Subjects and Methods: This study was carried out in Akpabuyo LGA of Cross River State from April to June 2016. It was a cross-sectional survey of anti-pertussis IgG levels in children aged 6 months to 5 years who received DPT and those who received pentavalent vaccine. IgG antibody levels were determined using enzyme-linked immunosorbent assay. The protective level was set at >11 DU according to manufacturer’s cut off point. Results: Seventy eight out of 230 children [33.9%] who had received DPT had protective levels of anti-pertussis IgG compared to 74 out of 192 children [38.5%] who had received pentavalent vaccine. The difference was not statistically significant [p = 0.61]. The median IgG antibody level in those who received DPT was 8.0 DU (interquartile range (IQR) 4.0 - 13.0) compared with 9.0 DU (IQR) 4.0 - 15.0 in those who received pentavalent vaccine [p = 0.18]. No single factor investigated predicted the development of protective levels of antibody in the multivariate analysis. Conclusion/Recommendation: There was no difference in the antipertussis antibody response between DPT and pentavalent vaccines recipients. Further study is needed to elucidate factors that could be responsible for low anti-pertussis antibody response in this population.
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