神经胶质瘤中Wnt-β-catenin信号通路相关长非编码RNA的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-01-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.01.013

X. Ren, Hu-Bin Duan, Youchao Xiao, J. Hao

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引用次数: 1

摘要

胶质瘤是中枢神经系统最常见的侵袭性恶性肿瘤之一。Wnt-β-catenin信号通路是典型的Wnt通路，参与胶质瘤等肿瘤的发生发展。长链非编码RNA (Long non-coding RNA, LncRNA)是一种不具有蛋白质编码功能的功能性RNA分子，在各种肿瘤的发生发展中发挥调控作用。近年来的研究表明，LncRNA和Wnt-β-catenin信号通路共同参与胶质瘤的生长、侵袭、迁移等过程，但其复杂机制尚未得到深入阐述。本文就Wnt-β-catenin信号通路及其相关LncRNA对胶质瘤的影响进行综述，深入了解胶质瘤的发病机制，以期为胶质瘤的诊断和治疗寻找更好的方法。关键词:胶质瘤;Wnt信号通路;Wnt-β-catenin信号通路;长链非编码RNA

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Progress of Wnt-β-catenin signaling pathway related long non-coding RNA in glioma

Glioma is one of the most common and invasive malignant tumors in the central nervous system. The Wnt-β-catenin signaling pathway is a classical Wnt pathway, which is involved in the occurrence and development of glioma and other tumors. Long non-coding RNA (LncRNA) is a functional RNA molecule without protein coding function, which plays a regulatory role in the occurrence and development of various tumors. Recent studies have shown that LncRNA and Wnt-β-catenin signaling pathways are jointly involved in glioma growth, invasion, migration and other processes, but the complex mechanism has not been thoroughly elaborated. In this paper, the influence of Wnt-β-catenin signaling pathway and its related LncRNA on glioma was reviewed, and the pathogenesis of glioma was deeply understood, so as to find a better way for the diagnosis and treatment of glioma. Key words: Glioma; Wnt signaling pathway; Wnt-β-catenin signaling pathway; Long non-coding RNA

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.