神经胶质瘤中Wnt-β-catenin信号通路相关长非编码RNA的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-01-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.01.013

X. Ren, Hu-Bin Duan, Youchao Xiao, J. Hao

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引用次数: 1

摘要

胶质瘤是中枢神经系统最常见的侵袭性恶性肿瘤之一。Wnt-β-catenin信号通路是典型的Wnt通路，参与胶质瘤等肿瘤的发生发展。长链非编码RNA (Long non-coding RNA, LncRNA)是一种不具有蛋白质编码功能的功能性RNA分子，在各种肿瘤的发生发展中发挥调控作用。近年来的研究表明，LncRNA和Wnt-β-catenin信号通路共同参与胶质瘤的生长、侵袭、迁移等过程，但其复杂机制尚未得到深入阐述。本文就Wnt-β-catenin信号通路及其相关LncRNA对胶质瘤的影响进行综述，深入了解胶质瘤的发病机制，以期为胶质瘤的诊断和治疗寻找更好的方法。关键词:胶质瘤;Wnt信号通路;Wnt-β-catenin信号通路;长链非编码RNA

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Progress of Wnt-β-catenin signaling pathway related long non-coding RNA in glioma

Glioma is one of the most common and invasive malignant tumors in the central nervous system. The Wnt-β-catenin signaling pathway is a classical Wnt pathway, which is involved in the occurrence and development of glioma and other tumors. Long non-coding RNA (LncRNA) is a functional RNA molecule without protein coding function, which plays a regulatory role in the occurrence and development of various tumors. Recent studies have shown that LncRNA and Wnt-β-catenin signaling pathways are jointly involved in glioma growth, invasion, migration and other processes, but the complex mechanism has not been thoroughly elaborated. In this paper, the influence of Wnt-β-catenin signaling pathway and its related LncRNA on glioma was reviewed, and the pathogenesis of glioma was deeply understood, so as to find a better way for the diagnosis and treatment of glioma. Key words: Glioma; Wnt signaling pathway; Wnt-β-catenin signaling pathway; Long non-coding RNA

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍：