多系统萎缩疾病进展的影像学标志物

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2019-08-01 DOI:10.2217/fnl-2018-0045

B. Heim, F. Krismer, W. Poewe, K. Seppi

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引用次数: 3

摘要

不同的神经成像模式有可能作为多系统萎缩（MSA）潜在神经退行性变的替代标志物，并可能反映细胞损失、葡萄糖代谢改变、小胶质细胞增殖、星形胶质细胞活化和黑质纹状体去神经支配。多项研究表明，一系列结构和功能成像研究能够定量证明MSA患者的神经退行性变，这使得可以根据这些神经成像标志物的进展率来估计样本量。这篇综述总结了最近的研究结果，作为评估MSA中系列神经成像衍生参数纵向变化的工具。

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Imaging markers of disease progression in multiple system atrophy

Different neuroimaging modalities hold potential as surrogate markers of underlying neurodegeneration in multiple system atrophy (MSA) and may reflect cell loss, altered glucose metabolism, microglial proliferation, astroglial activation, and nigrostriatal denervation. Multiple studies have demonstrated that serial structural and functional imaging studies are capable of demonstrating neurodegeneration in MSA patients quantitatively, which allows sample size estimates based on rates of progression of these neuroimaging markers. This review summarizes recent research findings as a tool to assess longitudinal changes of serial neuroimaging-derived parameters in MSA.

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.