TRIM56基因在SARS-CoV-2变异株中的表达及其与新冠肺炎进展的关系

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-06-01 Epub Date: 2023-07-13 DOI:10.2217/fvl-2022-0210

Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eybpoosh, Delaram Doroud, Iraj Ahmadi, Enayat Anvari, Mohammadreza Aghasadeghi, Abolfazl Fateh

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引用次数: 0

摘要

目的:本研究旨在确定α、δ和Omicron BA.5变异之间TRIM56差异表达水平与COVID-19严重感染的相关性。材料与方法:本研究纳入330例COVID-19患者，其中重度感染142例，轻度感染188例，健康对照160例。采用qPCR检测TRIM56基因表达水平。结果:TRIM56基因在重度组和轻度组的mRNA表达量明显低于健康人。我们的发现表明TRIM56 mRNA在Delta和Omicron BA.5变体中分别有高和低的表达减少。结论:TRIM蛋白对COVID-19严重程度的影响有待进一步研究。

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Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19.

Aim: The present study aimed to determine a correlation between differential TRIM56 expression levels and severe infections of COVID-19 between the Alpha, Delta and Omicron BA.5 variants.

Materials & methods: This study was performed on 330 COVID-19 patients, including 142 with severe and 188 with mild infections, as well as 160 healthy controls. The levels of TRIM56 gene expression were determined using a qPCR.

Results: TRIM56 gene showed significantly lower mRNA expression in the severe and mild groups compared with healthy individuals. Our finding indicated the high and low reduction of TRIM56 mRNA expression in Delta and Omicron BA.5 variant, respectively.

Conclusion: Further research is needed to characterize the impact of TRIM proteins on the severity of COVID-19.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.