朗格汉斯组织细胞增多症

Q4 Medicine

Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-01-01 DOI:10.4267/2042/70683

Dingbao Chen

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摘要

根据细胞学非典型性和临床侵袭性的程度，源自朗格汉斯细胞(LCs)的肿瘤分为两个主要亚群:LC组织细胞增生症(LCH)和LC肉瘤。这两个亚群都保持了LCs的表型特征和超微结构特征。LCH是表达CD1a、langerin和S100蛋白的langerhans型细胞的克隆性肿瘤增生，超微结构检查显示Birbeck颗粒。本文将讨论LCH的临床病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Langerhans cell histiocytosis

Tumours derived from Langerhans cells (LCs) are divided into two main subgroups, according to the degree of cytological atypia and clinical aggressiveness: LC histiocytosis (LCH) and LC sarcoma. Both subgroups maintain the phenotypic profile and ultrastructural features of LCs. LCH is a clonal neoplastic proliferation of Langerhans-type cells that express CD1a, langerin, and S100 protein, showing Birbeck granules by ultrastructural examination. Here the clinicopathological of LCH will be discussed.

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Atlas of Genetics and Cytogenetics in Oncology and Haematology Medicine-Oncology

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