使用智能手机应用程序与常规随访治疗晚期非小细胞肺癌(NSCLC)患者的初步研究

Journal of global oncology Pub Date : 2019-10-07 DOI:10.1200/jgo.2019.5.suppl.9

N. Prasongsook, K. Seetalarom, S. Saichaemchan, Kitipong Udomdamrongkul

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引用次数: 0

摘要

9背景：基于网络的患者报告结果（PRO）改善了接受特定治疗的晚期NSCLC患者的生活质量（QoL）和总生存率（OS）。Lung癌症Care应用程序是一个移动应用程序，为患者提供关于患者报告结果的个人定制信息。本研究旨在发明一种新的移动应用程序，用于评估泰国NSCLC患者的PRO，并评估移动应用程序的有效性。方法：我们设计了基于移动应用程序的PRO，用于监测生活质量。根据翻译和验证问卷的指导原则，对申请的有效性进行了测试。生活质量评分（FACT-L评分）。在验证了基于移动应用程序的PRO后，将晚期NSCLC患者随机分为使用基于移动应用的PRO和常规随访。主要终点是生活质量（QoL）。次要终结点是操作系统。结果：纳入了33例晚期NSCLC患者。基于移动应用程序的PRO组和常规随访组的基线FACT-L评分平均值相似（90.08±5.66 vs 91.78±5.26，p值=0.82）。移动应用程序组患者在3个月时的FACT-L评分高于常规随访组患者（106±5.97 vs 99.96±5.74，p值=0.07）基线和3个月的移动应用患者与常规随访患者相比（p值=0.05）。中位随访时间为5.43个月，与常规随访患者相比，移动应用的患者OS中位数更长（4个月vs 2.9个月，p值=0.5）。结论：基于自我报告症状的肺癌护理应用是一种新型的实时患者护理监测电子设备。我们的研究结果表明，使用这种新型移动应用程序有提高生活质量的趋势。然而，试点测试的样本很小，相对较大的采样误差可能会降低验证该工具所需的统计能力。

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A pilot study of using smartphone application versus routine follow up for patients' care in advanced non-small cell lung cancer (NSCLC).

9 Background: Web-based patient reported outcome (PRO) improved quality of life (QoL), and overall survival (OS) in patients with advanced NSCLC who were treating with specific therapy. Lung Cancer Care application is a mobile application program that provides patients with individually tailored information on patient reported outcome. This study aims to invent a novel mobile application evaluating PRO for Thai NSCLC patients, and to evaluate the validity of mobile application. Methods: Our mobile application-based PRO was designed for monitoring quality of life. The validity of the application was tested following guidelines for translating, and validating a questionnaire. The quality of life score (FACT-L score). After the validated mobile application-based PRO, patients with advanced NSCLC were randomized to use mobile application-based PRO versus routine follow-up. The primary endpoint was quality of life (QoL). Secondary endpoint was OS. Results: Thirty-three patients with advanced NSCLC were enrolled. The mean of FACT-L score at baseline in mobile application-based PRO arm and routine follow up arm was similar (90.08 ± 5.66 vs 91.78 ± 5.26, p-value= 0.82). Patients with mobile application group had more FACT-L score at 3 months than patients with routine follow up arm (106 ± 5.97 vs 99.96 ± 5.74, p-value = 0.07). There was a trend towards increased in different mean of FACT-L score at baseline and 3 months in patients with mobile application compared to patients with routine follow up ( p-value = 0.05). The median follow-up time was 5.43 months, patients with mobile application had longer median OS than patients with routine follow up (4 months vs 2.9 months, p-value = 0.5). Conclusions: Lung Cancer Care application based on self-reported symptoms is a novel electronic device for real-time patient care monitoring. Our study results showed trend towards improved quality of life from using this novel mobile application. However, there was small samples for pilot testing, the relatively large sampling errors may reduce the statistical power needed to validate this tool.

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来源期刊

Journal of global oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of Global Oncology (JGO) is an online only, open access journal focused on cancer care, research and care delivery issues unique to countries and settings with limited healthcare resources. JGO aims to provide a home for high-quality literature that fulfills a growing need for content describing the array of challenges health care professionals in resource-constrained settings face. Article types include original reports, review articles, commentaries, correspondence/replies, special articles and editorials.