Chioma Donlawson, Daniel Okechukwu Nweneka, kingsley John Orie, Reminus Okah
{"title":"1-(2-氨基甲酰胍)(呋喃-2-甲基)尿素的合成及生物活性研究","authors":"Chioma Donlawson, Daniel Okechukwu Nweneka, kingsley John Orie, Reminus Okah","doi":"10.4236/ajac.2020.117022","DOIUrl":null,"url":null,"abstract":"1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea was synthesised by coupling purified furfural with urea. The compound was characterized by GC-MS, FTIR, and 1H-NMR. The pathogens, Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis were isolated and screened with different concentrations of 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea. All the pathogens were susceptible to the synthesized compound except Bacillus subtilis. Due to this broad spectrum of activity, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl))urea) can be use for various medicinal purposes and is therefore encouraged for the development of a novel drug in future.","PeriodicalId":63216,"journal":{"name":"美国分析化学(英文)","volume":"11 1","pages":"280-288"},"PeriodicalIF":0.0000,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Synthesis and Bioactivity of 1-((2-Carbamoylguanidino) (furan-2-ylmethyl)urea\",\"authors\":\"Chioma Donlawson, Daniel Okechukwu Nweneka, kingsley John Orie, Reminus Okah\",\"doi\":\"10.4236/ajac.2020.117022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea was synthesised by coupling purified furfural with urea. The compound was characterized by GC-MS, FTIR, and 1H-NMR. The pathogens, Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis were isolated and screened with different concentrations of 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea. All the pathogens were susceptible to the synthesized compound except Bacillus subtilis. Due to this broad spectrum of activity, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl))urea) can be use for various medicinal purposes and is therefore encouraged for the development of a novel drug in future.\",\"PeriodicalId\":63216,\"journal\":{\"name\":\"美国分析化学(英文)\",\"volume\":\"11 1\",\"pages\":\"280-288\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"美国分析化学(英文)\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://doi.org/10.4236/ajac.2020.117022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"美国分析化学(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/ajac.2020.117022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Bioactivity of 1-((2-Carbamoylguanidino) (furan-2-ylmethyl)urea
1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea was synthesised by coupling purified furfural with urea. The compound was characterized by GC-MS, FTIR, and 1H-NMR. The pathogens, Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis were isolated and screened with different concentrations of 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea. All the pathogens were susceptible to the synthesized compound except Bacillus subtilis. Due to this broad spectrum of activity, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl))urea) can be use for various medicinal purposes and is therefore encouraged for the development of a novel drug in future.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
