动脉弹性:心血管风险、脉压、痴呆、衰老和药物靶向的联系

J. D’Arrigo
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引用次数: 1

摘要

与正常衰老相比,阿尔茨海默病患者的脑血管动脉粥样硬化和其他几种心血管(或“炎症性衰老”类型)疾病更频繁、更严重。此外,观察到的与痴呆症(及其相关的脑微血管损伤)的致病联系很容易通过动脉弹性的改变来解释。延迟痴呆症的治疗策略可以基于局部药物递送,使用脂质纳米载体(即基于生物的纳米乳液技术),靶向参与某些促炎、SAA介导的细胞信号事件的主要血清淀粉样蛋白A(SAA)受体。此外,通过将药物分子结合到这种脂质纳米载体中,可以获得一种“联合治疗”,能够同时(通过细胞表面清除剂受体)靶向各种细胞类型,每种细胞类型都可能与阿尔茨海默病和/或痴呆症有关,用于体内集中给药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arterial Elasticity: Linking of Cardiovascular Risks, Pulse Pressure, Dementia, Aging, and Drug Targeting
Cerebrovascular atherosclerosis, and several other cardiovascular (or "inflamm-aging" type) diseases, are more frequent and advanced in subjects with Alzheimer's disease compared with normal aging. In addition, the observed pathogenic link to dementia (and its associated cerebral microvascular damage) is readily explained by alterations of arterial elasticity. A therapeutic strategy to delay dementia could be based upon localized drug delivery, using lipid nanocarriers (i.e., biobased nanoemulsion technology), targeted toward a major serum amyloid A (SAA) receptor involved in certain proinflammatory, SAA-mediated, cell signaling events. Moreover, by incorporating drug molecules into such lipid nanocarriers, one can obtain a "combination therapeutic" capable of targeting simultaneously (via cell-surface scavenger receptors) a variety of cell types, each potentially implicated in Alzheimer's disease and/or dementia, for focused drug delivery in vivo.
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