CD20高表达血管免疫母细胞T细胞淋巴瘤5例临床特点及预后分析

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-10-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.10.013

Shao-jing Yang, Xiqing Chen, Zhuo Chen

{"title":"CD20高表达血管免疫母细胞T细胞淋巴瘤5例临床特点及预后分析","authors":"Shao-jing Yang, Xiqing Chen, Zhuo Chen","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.10.013","DOIUrl":null,"url":null,"abstract":"目的 \n探讨CD20阳性血管免疫母细胞性T细胞淋巴瘤（AITL）的临床病理学特征。 \n \n \n方法 \n对广东省佛山市第一人民医院诊治的1例及文献报道的4例CD20阳性AITL患者的临床病理学特征及预后进行分析。 \n \n \n结果 \n5例AITL患者中，男性4例，女性1例，平均年龄61岁。3例初诊时CD20阴性，复发时才表达CD20。3例出现误诊，其中2例误诊为非特指型外周T细胞淋巴瘤，1例误诊为弥漫大B细胞淋巴瘤。3例接受利妥昔单抗治疗，2例有效，1例无法评估疗效。 \n \n \n结论 \nCD20阳性AITL患者的临床病理特征易与B细胞淋巴瘤混淆，病理形态学、免疫组织化学及TCR基因重排检测等可减少误诊。利妥昔单抗是否有益尚不明确，应积极寻找有效的治疗方案，提高治愈率，改善患者预后。","PeriodicalId":9505,"journal":{"name":"肿瘤研究与临床","volume":"31 1","pages":"700-703"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Angioimmunoblastic T-cell lymphoma with high expression of CD20: clinical characteristics and prognosis analysis of five cases\",\"authors\":\"Shao-jing Yang, Xiqing Chen, Zhuo Chen\",\"doi\":\"10.3760/CMA.J.ISSN.1006-9801.2019.10.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"目的 \\n探讨CD20阳性血管免疫母细胞性T细胞淋巴瘤（AITL）的临床病理学特征。 \\n \\n \\n方法 \\n对广东省佛山市第一人民医院诊治的1例及文献报道的4例CD20阳性AITL患者的临床病理学特征及预后进行分析。 \\n \\n \\n结果 \\n5例AITL患者中，男性4例，女性1例，平均年龄61岁。3例初诊时CD20阴性，复发时才表达CD20。3例出现误诊，其中2例误诊为非特指型外周T细胞淋巴瘤，1例误诊为弥漫大B细胞淋巴瘤。3例接受利妥昔单抗治疗，2例有效，1例无法评估疗效。 \\n \\n \\n结论 \\nCD20阳性AITL患者的临床病理特征易与B细胞淋巴瘤混淆，病理形态学、免疫组织化学及TCR基因重排检测等可减少误诊。利妥昔单抗是否有益尚不明确，应积极寻找有效的治疗方案，提高治愈率，改善患者预后。\",\"PeriodicalId\":9505,\"journal\":{\"name\":\"肿瘤研究与临床\",\"volume\":\"31 1\",\"pages\":\"700-703\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"肿瘤研究与临床\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.10.013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"肿瘤研究与临床","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.10.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

Objective To investigate the clinical and pathological characteristics of CD20 positive vascular immunoblastic T-cell lymphoma (AITL). Method: The clinical pathological characteristics and prognosis of one case of CD20 positive AITL diagnosed and treated at the First People's Hospital of Foshan City, Guangdong Province, and four cases reported in the literature were analyzed. Among the 5 AITL patients, there were 4 males and 1 female, with an average age of 61 years. Three cases were negative for CD20 at initial diagnosis and only expressed CD20 at recurrence. Three cases were misdiagnosed, of which two were misdiagnosed as non-specific peripheral T-cell lymphoma and one was misdiagnosed as diffuse large B-cell lymphoma. 3 cases received rituximab treatment, 2 cases were effective, and 1 case was unable to evaluate the efficacy. Conclusion: The clinical pathological characteristics of CD20 positive AITL patients are easily confused with B-cell lymphoma, and pathological morphology, immunohistochemistry, and TCR gene rearrangement testing can reduce misdiagnosis. It is not yet clear whether rituximab is beneficial, and effective treatment plans should be actively sought to improve the cure rate and patient prognosis.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Angioimmunoblastic T-cell lymphoma with high expression of CD20: clinical characteristics and prognosis analysis of five cases

目的探讨CD20阳性血管免疫母细胞性T细胞淋巴瘤（AITL）的临床病理学特征。方法对广东省佛山市第一人民医院诊治的1例及文献报道的4例CD20阳性AITL患者的临床病理学特征及预后进行分析。结果 5例AITL患者中，男性4例，女性1例，平均年龄61岁。3例初诊时CD20阴性，复发时才表达CD20。3例出现误诊，其中2例误诊为非特指型外周T细胞淋巴瘤，1例误诊为弥漫大B细胞淋巴瘤。3例接受利妥昔单抗治疗，2例有效，1例无法评估疗效。结论 CD20阳性AITL患者的临床病理特征易与B细胞淋巴瘤混淆，病理形态学、免疫组织化学及TCR基因重排检测等可减少误诊。利妥昔单抗是否有益尚不明确，应积极寻找有效的治疗方案，提高治愈率，改善患者预后。

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.