脑深部刺激-治疗阿尔茨海默病的可能性

Ethan Fitzgerald, Dorian M Kusyk, N. Tomycz
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引用次数: 0

摘要

阿尔茨海默病(AD)是全球痴呆症的主要原因,也是认知能力下降、残疾和死亡率的重要原因。正在进行的临床试验继续研究β-淀粉样蛋白靶向治疗,其益处尚不清楚,目前我们仅限于症状治疗。因此,迫切需要开发新的、可能改变疾病的治疗策略,如脑深部刺激。本文综述了阿尔茨海默病中的深部脑刺激,从神经回路紊乱的角度描述了该疾病的病理生理学,并详细讨论了刺激穹窿、Meynert基底核和腹侧纹状体/腹侧包膜治疗该痴呆的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deep Brain Stimulation – Therapeutic Possibilities in Alzheimer's Disease
Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Disease, describing the pathophysiology of the disease in terms of disordered neural circuitry, and a detailed discussion on trails of stimulation of the fornix, the nucleus basalis of Meynert and the ventral striatum/ventral capsule for the treatment of this dementia.
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